DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and zfhx2

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_001335082.5	Gene:	zfhx2 / 795005	ZFINID:	ZDB-GENE-030131-6699	Length:	1529	Species:	Danio rerio

Alignment Length:	729	Identity:	136/729 - (18%)
Similarity:	232/729 - (31%)	Gaps:	209/729 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QEL-LGLAVAAATEAPTDLTTTAGATVAKERQTPT------PPKTTNATMATAATSAATAATPTN 67
            |:| |.|.:.|..:.||.|:.|     ..::..|.      |...:.|.::|...|....:.|::
Zfish   809 QDLDLDLQLEAQADPPTPLSIT-----VDQQGVPANILQSLPISLSLAPLSTQLYSPYVLSLPSS 868

  Fly    68 -----AAEGNLTSVSEPQQQPQQQQQEQQHHQPHHHQY---------------REHHQMT--MAA 110
                 .:||:...::....||.....:..:.....|.:               .::|..|  ::.
Zfish   869 VIGVGVSEGDRAKIAFSNTQPVSALSDPLNAPSTTHSFLSNGNDCESALDLSMGKNHSSTISVST 933

  Fly   111 ASRMAYFNAHAAVAAAFMPHQLAAAVHHHHQHQHQHHPHHHPHHPHGAVGGPPP--------PPP 167
            |:|.:...:|........|                           ..||.|..        .|.
Zfish   934 ANRPSIQKSHLLDGLGLRP---------------------------TTVGVPTDGGLIVVQVKPD 971

  Fly   168 MQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKKKR-- 230
            .....|...:..|::.....:..:....|...:..||..::...|         ..|::.:||
Zfish   972 SAIAIPSSTNSTLINRNNLAKTSTVYMRAAEKVTTSLIEREKEKE---------REKEQDQKRPK 1027

  Fly   231 -------RHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKT 288
                   |.||||..:.||:.|...:.:...|..:..|.:|....||:..:|:||||.||:.||.
Zfish  1028 VRRFRDMRRSRTIIHADQLDILYGCYFKDPNPGKHEFEQISEWVNLPKKVVQIWFQNMRARERKG 1092

  Fly   289 EKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKS-AKDNDAVAP-WLLGMEQKCMHRKSIEAQSAL 351
            |..:.....:|..|  ..:::.:.||...|..: .|.|.:.:. |.....|.......||....:
Zfish  1093 EVRFISDGTLAAVG--KPLIKFTWPLSKPIFSNPPKSNTSPSTGWTSAKPQTGNILPKIEKLKEV 1155

  Fly   352 KDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAP-------SSCPTSASTSAPP 409
            |:.           .|:.|.   ..||    .:.|.|..|||.:|       ...|.:....||.
Zfish  1156 KEP-----------LKAPHQ---GPSR----PNQTTSFTVVSTSPLIQKIKTEVAPITMVKIAPK 1202

  Fly   410 TSTSGYAGAASSAATTP-------TGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYL 467
            |            .|||       :|..|:.|:....:|   ....:.:|.. ::....|..|..
Zfish  1203 T------------VTTPVAVPLLVSGIPTSRSAPKRKVE---EVQAESEHTD-EEDDHCQGGLES 1251

  Fly   468 GAGAVVTGCAPPSYHPLLDAANAAGAGAAASSKDFHM---------IMNT--------------- 508
            |...::.        |.|.........|.||.|...:         .:||
Zfish  1252 GTTNLMV--------PKLTTTPINKPAALASQKQNGLKYWPQKGPFKINTLSREQLGLSSQRPTA 1308

  Fly   509 -------AVAAAAAAAQQQHQQQQQQQQQATATAPGLHAHNLAAALMEHDPDAFRNNSIACLRAK 566
                   :.....|:..|..::....||.:|...|..|..:|..::::...:       .|....
Zfish  1309 TTTPTTPSPLTVTASPSQSQKEISYMQQNSTPRRPRTHLTSLQLSILQSCYE-------TCAHPN 1366

  Fly   567 AQEHQARLLNNGGLFLQV------------RRFAQGQAQI----QDPSDMLKLSE----EHN--- 608
            |.|.:| :....||.|:|            :|:...|.::    .|||..:.:|.    ::|
Zfish  1367 ALECEA-VGTELGLPLKVVQIWFQNTRAKEKRWRLQQEKMSPNPSDPSKKIDVSSGSYLQYNALR 1430

  Fly   609 NNSPIPIPPAHSTV 622
            .|.||...|...||
Zfish  1431 ANRPILPKPVQLTV 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	19/52 (37%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777	2/13 (15%)
zfhx2	XP_001335082.5	C2H2 Zn finger	171..193	CDD:275368
		C2H2 Zn finger	223..241	CDD:275368
		Homeobox	1039..1090	CDD:278475	17/50 (34%)
		HOX	1340..1396	CDD:197696	11/63 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174754at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010