Protein Alignment Vsx2 and SHOX

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 82/273 - (30%)
• Similarity: 107/273 - (39%)
• Gaps: 77/273 - (28%)

  Fly   189 LKSFAAGAGTCLPGSLAPK--DFGMESLNGFGVGP------NSKKK-------------KKKRRH 232
            |:....|.|.| |..|...  |...|.|..||...      ..|:|             |.|:|.
Human    56 LQDITEGGGHC-PVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRR 119

  Fly   233 SRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTI 297
            |||.||..||.:||..|.|.||||.:.||.||.:..|.|.|:||||||||||.||.|.
Human   120 SRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQEN------- 177

  Fly   298 MAEYGLYGAMVRHSLPLPDTILKSAKDNDA--VAPWLLGMEQKCMHRKSIEAQSALKDDSGVSD- 359
                      ..|.    ..||.:|...||  |||: :.|....|..:.::||..|:   ||:.
Human   178 ----------QMHK----GVILGTANHLDACRVAPY-VNMGALRMPFQQVQAQLQLE---GVAHA 224

  Fly   360 HEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAAT 424
            |.......:||:..|                :..|.|...|.::           .|.:||:||.
Human   225 HPHLHPHLAAHAPYL----------------MFPPPPFGLPIAS-----------LAESASAAAV 262

  Fly   425 TPTGASTTNSSSS 437
            ....|.:.:.:||
Human   263 VAAAAKSNSKNSS 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	33/56 (59%)
		OAR	556..572	CDD:461067
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		3/18 (17%)
		Homeodomain	118..174	CDD:459649	33/55 (60%)
		SH3-binding. /evidence=ECO:0000255	242..249		2/6 (33%)
		OAR	272..288	CDD:461067	2/4 (50%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287		2/2 (100%)