DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vsx2 and lhx4

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001116445.1	Gene:	lhx4 / 571943	ZFINID:	ZDB-GENE-060728-1	Length:	391	Species:	Danio rerio

Alignment Length:	242	Identity:	66/242 - (27%)
Similarity:	93/242 - (38%)	Gaps:	60/242 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGS 295
            :..||..|:.|||.|:.|:|.:..|..:.||.||.:|.|....:||||||||||.::.:|..|
Zfish   161 KRPRTTITAKQLETLKSAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAG-- 223

  Fly   296 TIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDH 360
                         ||..   ....||.|.|...:             |:.:..||  ||:|:||.
Zfish   224 -------------RHRW---GQFYKSVKRNRGSS-------------KTEKESSA--DDAGLSDS 257

  Fly   361 E-----DSAGSKSAHSEDL-----SRSRCHALSSS---------TESLNVVSP-----APSSCPT 401
            |     |...|...|:..|     ..|..:.|:.|         ...|...||     :|||. |
Zfish   258 ELSFRDDQILSDLGHANGLYGSVGDVSNGNMLNGSFSLDGGGQPYHDLRAGSPYGLPQSPSSI-T 321

  Fly   402 SASTSAPPTSTSGYA--GAASSAATTPTGASTTNSSSSPHIELGSPS 446
            |.....|..:..|::  |....|.....|.:....:..|..:|.:.|
Zfish   322 SLPGHTPLLNNLGFSMDGLMGQAGQPSVGQALRAMAGGPTSDLSTGS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	26/52 (50%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
lhx4	NP_001116445.1	LIM1_Lhx4	33..84	CDD:188852
		LIM2_Lhx3_Lhx4	92..147	CDD:188762
		Homeobox	163..216	CDD:278475	26/52 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174754at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010