Protein Alignment Vsx2 and OTX2

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 79/297 - (26%)
• Similarity: 113/297 - (38%)
• Gaps: 102/297 - (34%)

  Fly   228 KKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVW 292
            :|:|..||.||..||:.||..|.:..|||::.||.::||..|||.|:||||:|||||.|:.::..
Human    44 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 108

  Fly   293 --GGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDS 355
              ||                              .:.|.|          .:|.......:..:|
Human   109 QNGG------------------------------QNKVRP----------AKKKTSPAREVSSES 133

  Fly   356 GVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPA---PSSCPTSASTSA-----PPTST 412
            |.|.......|.|..:          ::||:..:::.|||   |.|.|.|.|:|.     |.|.|
Human   134 GTSGQFTPPSSTSVPT----------IASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYT 188

  Fly   413 ------SGYAGAASSAATTPTGASTTNSSSSP-HIELGSP----SPQQQQHLQLQQQQQQQASLY 466
                  .||||     :|:..|.....|..:| |.:|..|    ||
Human   189 QASGYSQGYAG-----STSYFGGMDCGSYLTPMHHQLPGPGATLSP------------------- 229

  Fly   467 LGAGAVVTGCAPPSYHPLLDAANAAGAGAAASSKDFH 503
            :|..||.:       |.....|:.:..|..|||..|:
Human   230 MGTNAVTS-------HLNQSPASLSTQGYGASSLGFN 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	30/56 (54%)
		OAR	556..572	CDD:461067
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	30/54 (56%)
		TF_Otx	161..242	CDD:427350	29/111 (26%)