DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and PHOX2A

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_005160.2	Gene:	PHOX2A / 401	HGNCID:	691	Length:	284	Species:	Homo sapiens

Alignment Length:	356	Identity:	95/356 - (26%)
Similarity:	121/356 - (33%)	Gaps:	143/356 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 HGAVGGPPPPPPMQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSL----------APKDFG 210
            :|..|....|...|    :.|..|...|.|.|   ..|.|:..|..|:|          .|..|.
Human    21 YGDFGACSQPGGFQ----YSPLRPAFPAAGPP---CPALGSSNCALGALRDHQPAPYSAVPYKFF 78

  Fly   211 MESLNGFGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQ 275
            .|        |:...:|:|:|..||.|||.||::||..|.|.||||:|.||.|:||.:|.|.|:|
Human    79 PE--------PSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQ 135

  Fly   276 VWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCM 340
            |||||||||:||.|:   .::.....|..||
Human   136 VWFQNRRAKFRKQER---AASAKGAAGAAGA---------------------------------- 163

  Fly   341 HRKSIEAQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSAST 405
              |..||:.:.:||                  |...|.|             ||.|.|     :.
Human   164 --KKGEARCSSEDD------------------DSKESTC-------------SPTPDS-----TA 190

  Fly   406 SAPPTSTSGYAGAASSAATTPTGASTTNSSSSPHIELGS-----PSPQQQQHLQLQQQQQQQASL 465
            |.||....|.|....|.:..|             :.|||     |.||..:
Human   191 SLPPPPAPGLASPRLSPSPLP-------------VALGSGPGPGPGPQPLK-------------- 228

  Fly   466 YLGAGAVVTGCAPPSYHPLLDAANAAGAGAA 496
                ||:..|.|.       ......|||||
Human   229 ----GALWAGVAG-------GGGGGPGAGAA 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	34/52 (65%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
PHOX2A	NP_005160.2	Homeobox	94..147	CDD:365835	34/52 (65%)
PHOX2A	NP_005160.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..284		40/217 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810