DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vsx2 and unc-4

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	135/555 - (24%)
Similarity:	172/555 - (30%)	Gaps:	224/555 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ATAATSAATAATPTNA--AEGNLTSVSEPQQQPQQQQQEQQHHQPHHHQYREHHQMTMAAASR-- 113
            :.||.:|||.....||  |..|||.:|                               |||.|
  Fly   151 SAAAAAAATQMAAVNASNAFANLTGLS-------------------------------AAALRNV 184

  Fly   114 -MAYFNAHAAVAA--AFMPHQLAAAVHHHHQHQHQHHPHHHPHHPHGAVGG----PPPPPPMQHH 171
             .|...|.||||:  |.:.|:|                         .:|.    ||..||.:
  Fly   185 SAAQTTAVAAVASTVATIQHRL-------------------------MIGNRQSLPPAGPPSE-- 222

  Fly   172 HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKKKRRHSRTI 236
                                                  |.....||....:......|||.|||.
  Fly   223 --------------------------------------GSNEDGGFPGDGDDDSSAAKRRRSRTN 249

  Fly   237 FTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGG------- 294
            |.|:|||:||.||..:||||::.||.|:::.:|.|.|:.|||||||||.||.|....|
  Fly   250 FNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGPGRPAHN 314

  Fly   295 ---STIMAEYGLYGAMVRHSLPLPDTILKS----------AKDNDAVAPWL-----------LGM 335
               .|...|            |:|...||:          ||..|..|..|           |..
  Fly   315 AQPQTCSGE------------PIPPNELKAKERARRRKKLAKAIDRQARKLQAKGITVDLEALKA 367

  Fly   336 EQKCMHR-KSIEAQSALKDDS------GVSDHED---------------------------SAGS 366
            |....|: ....:.|.|:||.      |.:|.:|                           ...|
  Fly   368 EYISQHKANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGGGGGAS 432

  Fly   367 KSAH---SEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTPTG 428
            .|.|   ..|...||..:......||.           |.|:.|||:..|.  ||.......|..
  Fly   433 SSLHCGLDGDGDSSRAGSFIGGGGSLG-----------SPSSVAPPSMLSN--GAVQFGKLEPMD 484

  Fly   429 ASTTNSSSSPHIELGSPSP-----QQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSYHPLLDAA 488
            .   |.|.....|..||.|     :....|.||..||.. .|.:|.|.              .:.
  Fly   485 G---NESEERDRERDSPKPLLFPAKAFHQLNLQSSQQHH-GLVVGQGQ--------------GSG 531

  Fly   489 NAAGAGAAASSKDFHMIMNTAVAAAAAA-AQQQHQ 522
            :..|.|...:....|:...:|.|:|||| |...||
  Fly   532 SGHGHGHQHNHHQHHLHHGSASASAAAAVANLVHQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	31/52 (60%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	31/52 (60%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450912
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840