DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and VSX1

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_055403.2	Gene:	VSX1 / 30813	HGNCID:	12723	Length:	365	Species:	Homo sapiens

Alignment Length:	435	Identity:	155/435 - (35%)
Similarity:	188/435 - (43%)	Gaps:	128/435 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPQRSP-------FAIQELLGL-AVAAATEAPTDLTTTAGATVAKERQTPTPPKTTNATMATAAT 57
            :|..||       |||.:|||| |...|...|...:...|..||     |.|....:      .:
Human    18 VPGGSPRGSRPRGFAITDLLGLEAELPAPAGPGQGSGCEGPAVA-----PCPGPGLD------GS 71

  Fly    58 SAATAATPTNAAEGNLTSVSEPQQQPQQQQQEQQHHQPHHHQYREHHQMTMAAASRMAYFNAHAA 122
            |.|..|.|...  |.|....   .||.
Human    72 SLARGALPLGL--GLLCGFG---TQPP-------------------------------------- 93

  Fly   123 VAAAFMPHQLAAAVHHHHQHQHQHHPHHHPHHPHGAVG-GPPPPPPMQHHHPHHPHHPLLHAQGF 186
             |||..|..|.|.|           |...|..|..|.. .|..|||               |.|
Human    94 -AAARAPCLLLADV-----------PFLPPRGPEPAAPLAPSRPPP---------------ALG- 130

  Fly   187 PQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKE 251
            .|.:|.:.        |.:.:|...|..|.....| :..|:||||| ||:||::|||:||:||.|
Human   131 RQKRSDSV--------STSDEDSQSEDRNDLKASP-TLGKRKKRRH-RTVFTAHQLEELEKAFSE 185

  Fly   252 AHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPD 316
            ||||||||||||::||||||||||||||||||||||.||.||||::|||||||||||||.:||||
Human   186 AHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPD 250

  Fly   317 TILKSAKDN--DAVAPWLLGMEQKCMH--RK--------SIEAQSALKDDSGVSDHEDSAGSKSA 369
            ::|.||:..  .:.|||||||.:|.|.  ||        .:......|:.|..|:.....||...
Human   251 SVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSDHFKEGSSQSESGSQRGSDKV 315

  Fly   370 HSE--------DLSRSRCHALSSSTESLNVVSPAPSSCPTSASTS 406
            ..|        |||       ||:.:....|.|...:...|.||:
Human   316 SPENGLEDVAIDLS-------SSARQETKKVHPGAGAQGGSNSTA 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	43/52 (83%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		6/18 (33%)
		Octapeptide motif	31..38		4/6 (67%)
		DNA_pol3_delta2	<47..>149	CDD:331068	35/191 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..167		19/78 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		3/4 (75%)
		Homeobox	167..220	CDD:306543	44/53 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..365		16/71 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6348
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002963
OrthoInspector	1	1.000	-	-		otm41172
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.800