DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vsx2 and arxa

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_571459.1	Gene:	arxa / 30657	ZFINID:	ZDB-GENE-990415-15	Length:	453	Species:	Danio rerio

Alignment Length:	403	Identity:	110/403 - (27%)
Similarity:	148/403 - (36%)	Gaps:	164/403 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 CLPGSLAPKDFGMESLNGFG------------VGPNSKK---KKKKRRHSRTIFTSYQLEKLEEA 248
            |...||:|||  .|||:..|            .|.:|::   |:|:||: ||.|||||||:||.|
Zfish   172 CGDNSLSPKD--EESLHNDGDVKDGEDSVCLSAGSDSEEGMLKRKQRRY-RTTFTSYQLEELERA 233

  Fly   249 FKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRH--S 311
            |::.|||||:.||.|:::.:|.|.|:|||||||||||||.||              ..:..|  .
Zfish   234 FQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK--------------AGVQAHPTG 284

  Fly   312 LPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHEDSAGSKSAHSEDLSR 376
            ||.|..:
Zfish   285 LPFPGPL---------------------------------------------------------- 291

  Fly   377 SRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTPTGASTTNSSSSP--- 438
            :..|.||...|.    .|.|        ....|...|.:..||::||..|..|...|||:.|
Zfish   292 AAAHPLSHYLEG----GPFP--------PHPHPALESAWTAAAAAAAAFPGLAPPPNSSALPPAT 344

  Fly   439 HIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSYHPLLDAANAAGAGAAASSKDFH 503
            .:.||:                     :||....        .||   |......|...||
Zfish   345 PLGLGT---------------------FLGTAMF--------RHP---AFIGPTFGRLFSS---- 373

  Fly   504 MIMNTAVAAAAAAAQQQHQQQQQQQQQATATAPGLHAHNLAAALMEHDPDAF-------RNNSIA 561
            |...|:.:.|||..:|              |||.:.:....:|.:...|.:.       |.:|||
Zfish   374 MGPLTSASTAAALLRQ--------------TAPPVESPVQPSAALPEPPSSSSSTAADRRASSIA 424

  Fly   562 CLRAKAQEHQARL 574
            .||.||:||.|:|
Zfish   425 ALRLKAKEHSAQL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	34/52 (65%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777	8/13 (62%)
arxa	NP_571459.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..212		12/41 (29%)
		Homeobox	219..271	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..418		5/27 (19%)
		OAR	417..434	CDD:281777	9/16 (56%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	421..434		8/12 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.880