DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and rx3

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_571302.1	Gene:	rx3 / 30474	ZFINID:	ZDB-GENE-990415-238	Length:	292	Species:	Danio rerio

Alignment Length:	349	Identity:	90/349 - (25%)
Similarity:	118/349 - (33%)	Gaps:	162/349 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 NSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWR 286
            :.:..|||.|.:||.||::||.:||.||:::||||||:||.|:||..|||.|:||||||||||||
Zfish    98 DDENPKKKHRRNRTTFTTFQLHELERAFEKSHYPDVYSREELALKVNLPEVRVQVWFQNRRAKWR 162

  Fly   287 KTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSAL 351
            :.||:...|..:.|..:        |.:|.:...|......:.|||.|
Zfish   163 RQEKLEVSSIKLQESSM--------LSIPRSGPLSLGSGLPLEPWLTG----------------- 202

  Fly   352 KDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYA 416
                                 .:|.|     ||..:||........:.|.|.:   ||...|
Zfish   203 ---------------------PISTS-----SSPLQSLPSFITPQQAVPASYT---PPQFLS--- 235

  Fly   417 GAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSY 481
                         |:|.:.|.|||                             |||   |.|...
Zfish   236 -------------SSTLNHSLPHI-----------------------------GAV---CPPYQC 255

  Fly   482 HPLLDAANAAGAGAAASSKDFHMIMNTAVAAAAAAAQQQHQQQQQQQQQATATAPGLHAHNLAAA 546
            ...:|                                                         ..:
Zfish   256 SGFMD---------------------------------------------------------KFS 263

  Fly   547 LMEHDPDAFRNNSIACLRAKAQEH 570
            |.|.||   ||.|||.||.||:||
Zfish   264 LQEADP---RNTSIASLRMKAKEH 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	35/52 (67%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777	9/13 (69%)
rx3	NP_571302.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Octapeptide motif	32..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..107		3/8 (38%)
		Homeobox	110..162	CDD:278475	35/51 (69%)
		OAR	268..284	CDD:281777	11/18 (61%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	272..285		9/13 (69%)
		Nuclear localization signal. /evidence=ECO:0000255	278..282		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920