Protein Alignment Vsx2 and ALX3

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_006483.2
• Gene: ALX3 / 257
• HGNCID: 449
• Length: 343
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 90/323 - (27%)
• Similarity: 122/323 - (37%)
• Gaps: 107/323 - (33%)

  Fly   148 PHHHPHHPHG-------AVG----------GPP--------PPPPMQHHH----PHHPHHPLLHA 183
            ||.||..|.|       |.|          .||        |.|.:...|    |.........|
Human    36 PHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKA 100

  Fly   184 QGFPQL------------KSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNS---KKKKKKRRHS 233
            ..||||            .:.....|.||.....|...|:         |:|   .|.|.|:|.:
Human   101 ASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLHLPLSPGL---------PDSMELAKNKSKKRRN 156

  Fly   234 RTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIM 298
            ||.|:::|||:||:.|::.|||||||||.|:|:|:|.|.|:|||||||||||||.|:
Human   157 RTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER-------- 213

  Fly   299 AEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHEDS 363
                 ||.:.....|.      :|..:.:|.|             ..::...|::....|....|
Human   214 -----YGKIQEGRNPF------TAAYDISVLP-------------RTDSHPQLQNSLWASPGSGS 254

  Fly   364 AGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTP 426
            .|..           |           :|||.....|..:..|.|..|.:|:.|..:.:|..|
Human   255 PGGP-----------C-----------LVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAHP 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	36/56 (64%)
		OAR	556..572	CDD:461067
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		15/67 (22%)
		PRK12323	<13..131	CDD:481241	22/94 (23%)
		Homeodomain	154..210	CDD:459649	36/55 (65%)