Protein Alignment Vsx2 and Alx1

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001408403.1
• Gene: Alx1 / 216285
• MGIID: 104621
• Length: 377
• Species: Mus musculus
• Alignment Length: 494
• Identity: 111/494 - (22%)
• Similarity: 155/494 - (31%)
• Gaps: 210/494 - (42%)

  Fly   164 PPPPMQHH---------HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGM---ESLNG 216
            |.|..:||         .....::.:...:|.|...........|....::|.. ||   ..|:.
Mouse    55 PLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNNLRMSPVK-GMPEKSELDE 118

  Fly   217 FGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNR 281
            .|...:|.....|:|..||.|||.|||:||:.|::.||||||.||.|:|:|||.|.|:|||||||
Mouse   119 LGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNR 183

  Fly   282 RAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIE 346
            ||||||.|:             ||.:
Mouse   184 RAKWRKRER-------------YGQI--------------------------------------- 196

  Fly   347 AQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTS 411
                           ..|.|..|.:.|:|                |.|...|.|
Mouse   197 ---------------QQAKSHFAATYDIS----------------VLPRTDSYP----------- 219

  Fly   412 TSGYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLG---AGAVV 473
                                                            |.|.:|:.|   .|:||
Mouse   220 ------------------------------------------------QIQNNLWAGNASGGSVV 236

  Fly   474 TGC----------APPSYHPLLDAANAAGAGAAASSKDF-HMIMNTAVA-AAAAAAQQQHQQQQQ 526
            |.|          .|.|:.|..|::.   .|.:.....| |:.:|.... :....|...|
Mouse   237 TSCMLPRDASSCMTPYSHSPRTDSSY---TGFSNHQNQFSHVPLNNFFTDSLLTGATNGH----- 293

  Fly   527 QQQQATATAPGLHAHNLAAALMEHDPDAFRNNSIACLRAKAQEHQARLLNNGGLF-LQVRRFAQG 590
                |..|.|....               |::|||.||.||:||.|.:  :..:| :.|.....|
Mouse   294 ----AFETKPEFER---------------RSSSIAVLRMKAKEHTANI--SWAMFDITVHSLLPG 337

  Fly   591 QAQIQDPSDMLKLSEEHNNNSPIPIPPAHSTVNTQVNVK 629
            |. :..|:..| ||.        |.||....::.:.:.|
Mouse   338 QC-LHIPAGFL-LSH--------PSPPGLMNISARKSEK 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	38/56 (68%)
		OAR	556..572	CDD:461067	10/15 (67%)
Alx1	NP_001408403.1	Homeodomain	133..189	CDD:459649	38/55 (69%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		44/304 (14%)
		OAR	302..320	CDD:461067	10/32 (31%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		8/12 (67%)