DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and Vsx2

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_017449515.1	Gene:	Vsx2 / 171360	RGDID:	621215	Length:	380	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	129/316 - (40%)
Similarity:	159/316 - (50%)	Gaps:	95/316 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 HPHGAVGGPPPPPPMQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTC-------LPGSLAPKDFGM 211
            ||..|:.|..            |.| ||.|:....    .||.|:.       |||..|...| :
  Rat    48 HPRAALDGLA------------PGH-LLAARSVLS----PAGVGSMGLLGPGGLPGFYAQPTF-L 94

  Fly   212 ESLN----------GFGVGP--------------------------NSKKKKKKRRHSRTIFTSY 240
            |.|:          |...||                          |..||:||||| |||||||
  Rat    95 EVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRH-RTIFTSY 158

  Fly   241 QLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYG 305
            |||:||:||.|||||||||||||::||||||||||||||||||||||.||.||.|::||||||||
  Rat   159 QLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYG 223

  Fly   306 AMVRHSLPLPDTILKSAKDN--DAVAPWLL---GMEQKC-----------MHRKSIEAQS----- 349
            ||||||:|||::|||||||.  |:.|||||   |..::.           ||:||:||.:
  Rat   224 AMVRHSIPLPESILKSAKDGIMDSCAPWLLVQDGFPRRFSKPEYQQFFLGMHKKSLEAAAESGRK 288

  Fly   350 ------------ALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVS 393
                        .::.:....|.:.:...:......::..|..|...||:.|..||
  Rat   289 PEVERQVLPKLDKMEQEERAPDAQAAISQEELRENSIAALRAKAQEHSTKVLGTVS 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	46/52 (88%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Vsx2	XP_017449515.1	Homeobox	153..205	CDD:395001	44/51 (86%)
Vsx2	XP_017449515.1	OAR	319..337	CDD:397759
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6220
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002963
OrthoInspector	1	1.000	-	-		otm45313
orthoMCL	1	0.900	-	-		OOG6_109254
Panther	1	1.100	-	-	O	PTHR46892
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5856
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.770