DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and Alx3

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_031467.1	Gene:	Alx3 / 11694	MGIID:	1277097	Length:	343	Species:	Mus musculus

Alignment Length:	324	Identity:	91/324 - (28%)
Similarity:	124/324 - (38%)	Gaps:	109/324 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 PHHHPHHPHG------AVGGP-------PPPPPMQHHHPHHPHHPLLH----------------- 182
            ||.||..|.|      ...||       |..||.::.....| .|:|:
Mouse    36 PHLHPAPPRGPRLSRFPACGPLEPYLPEPAKPPAKYLQDLGP-GPVLNGGHFYEGSAEAEEKASK 99

  Fly   183 AQGFPQL------------KSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNS---KKKKKKRRH 232
            |..||||            .:..|..|.||.....|...|:         |:|   .|.|.|:|.
Mouse   100 AASFPQLPVDCRGGPRDGPSNVQASPGPCLASLSVPLSPGL---------PDSMELAKTKSKKRR 155

  Fly   233 SRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTI 297
            :||.|:::|||:||:.|::.|||||||||.|:|:|:|.|.|:|||||||||||||.|:
Mouse   156 NRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER------- 213

  Fly   298 MAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHED 362
                  ||.|                 .:...|:....:...:.|.....|  |::....|....
Mouse   214 ------YGKM-----------------QEGRNPFTTAYDISVLPRTDSHPQ--LQNSLWPSPGSG 253

  Fly   363 SAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTP 426
            |.|....              .|.|.:    |:|...|.|.|..    :.:|:.|..:|.|..|
Mouse   254 SPGGPCL--------------MSPEGI----PSPCMSPYSHSHG----NVAGFMGVPASPAAHP 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	34/52 (65%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Alx3	NP_031467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..122		19/86 (22%)
		SP2	32..>141	CDD:281067	25/114 (22%)
		Homeobox	157..209	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.880