DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and vsx2

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_004917101.1	Gene:	vsx2 / 100493176	XenbaseID:	XB-GENE-853775	Length:	377	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	129/344 - (37%)
Similarity:	161/344 - (46%)	Gaps:	122/344 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 PPPPPMQHHHPHHPHHPLLHAQ---------GFP------------------QLKSFAAGAGTC- 199
            ||.|..:|.||..|...||.|:         |.|                  |......|:.||
Frog    28 PPTPSQRHLHPLSPGTHLLAARSGLGLLAAGGIPTFYTQPGLLLGDPPGPRIQQTGQEEGSRTCS 92

  Fly   200 ------------LPGSLAPKDFGMESLNGFGVGPNSKKKKKKRRHS------------------- 233
                        ||.||                 :..||:|||||.
Frog    93 SDSEDVSSSDRKLPKSL-----------------SQSKKRKKRRHRYPNIMFEGNRPKIKFGVFT 140

  Fly   234 ---------RTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTE 289
                     ||||||||||:||:||.|||||||||||||::||||||||||||||||||||||.|
Frog   141 GNKGAIRSFRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKRE 205

  Fly   290 KVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDN--DAVAPWLL---GMEQ------------ 337
            |.||.|::||||||||||||||:|||::|||||||.  ::.|||||   |::.
Frog   206 KCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMESCAPWLLVQDGLQMPRRFSKPEYQQF 270

  Fly   338 -KCMHRKSIEAQS-----------ALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTE--S 388
             ..||:|::||.:           ||......::..:...|.....|:|..:...||.:..:  |
Frog   271 FAGMHKKTLEAAADRVQQPEREAPALPSQPTANERREPELSAPISEEELRENSIAALRARAQEHS 335

  Fly   389 LNVVSPAPSSCPTSASTSA 407
            ..|:.      .|::.|||
Frog   336 AKVLR------STNSETSA 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	46/80 (58%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
vsx2	XP_004917101.1	Homeobox	150..203	CDD:365835	47/52 (90%)
vsx2	XP_004917101.1	OAR	318..336	CDD:367680	3/17 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6281
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002963
OrthoInspector	1	1.000	-	-		otm48385
Panther	1	1.100	-	-	O	PTHR46892
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2566
SonicParanoid	1	1.000	-	-		X5856
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040