DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and phox2b

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001116492.1	Gene:	phox2b / 100124329	XenbaseID:	XB-GENE-1000415	Length:	293	Species:	Xenopus tropicalis

Alignment Length:	308	Identity:	91/308 - (29%)
Similarity:	116/308 - (37%)	Gaps:	103/308 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 AQGF---PQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGP------------NSKKKKKKRRH 232
            |.||   |...:|.|.:| |  .||.|....:.:|......|            ....:|:|:|.
Frog    39 ASGFQYNPIRTTFGATSG-C--PSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRR 100

  Fly   233 SRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTI 297
            .||.|||.||::||..|.|.||||:|.||.|:||.:|.|.|:||||||||||:||.|:....:..
Frog   101 IRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAA 165

  Fly   298 MAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHED 362
            .|:.|                                             .|..|.||  |..|:
Frog   166 AAKNG---------------------------------------------SSGKKSDS--SRDEE 183

  Fly   363 SAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSC-----PTSASTSAPP------------- 409
            |..||||..:           |:....|..:|.| ||     |:.|..:..|
Frog   184 SKDSKSADPD-----------STGGPGNNPNPTP-SCGGGPSPSGAQGNGVPQEPGKVGVPGPGS 236

  Fly   410 -TSTS--GYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQ 454
             ||.|  |.:|.....||.|.|..|:...|     ||.|.......||
Frog   237 LTSASVVGVSGGPQGWATGPGGTITSIPDS-----LGGPFASVLSSLQ 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	34/52 (65%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
phox2b	NP_001116492.1	Homeobox	102..154	CDD:278475	34/51 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910