DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frma and ECE2

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	745	Identity:	152/745 - (20%)
Similarity:	265/745 - (35%)	Gaps:	212/745 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRLLELIVGLLV---VQVKSHPQ-----------------------ADPCQNFYKVACGNWSASH 43
            |.|..|::|.||   ||....|.                       ..||::||:.:||.|...:
Human   114 LLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRN 178

  Fly    44 ----ATDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYTACRK------------- 91
                ....:.:|....|.| |..|..||:|...:......|:.:.||.:|.:
Human   179 PLPDGRSRWNTFNSLWDQN-QAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLR 242

  Fly    92 -------------PLSQDQVLRILEHLIVMENIQNEELSVGLTAAFRLQVLIDLNDSNT----YD 139
                         |..||..:.:|:.:..         :...|..|.:.:..|...||:    .|
Human   243 DLIEKIGGWNITGPWDQDNFMEVLKAVAG---------TYRATPFFTVYISADSKSSNSNVIQVD 298

  Fly   140 IWKQLMSHRKHWDPNTTNREPLTR--EMFDKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSED 202
            .....:..|.::...|.|.:.||.  :..::|...|...|...:| ..:::.|||.::.:.....
Human   299 QSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTRE-QMQQVLELEIQLANITVPQ 362

  Fly   203 D----------GFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKL 257
            |          .....:|....|   .|.|      .|.||.:...|::..:|.::.|....|:.
Human   363 DQRRDEEKIYHKMSISELQALAP---SMDW------LEFLSFLLSPLELSDSEPVVVYGMDYLQQ 418

  Fly   258 VAEGVS-TESWHIDRDQCAEQSRQILSHPAAW-LVEKNHPRL------KEEPVLQDIFAELKQ-- 312
            |:|.:: ||.             .||::...| ||:|....|      .:|.:|:.::...|.
Human   419 VSELINRTEP-------------SILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 470

  Fly   313 -RFGQKLLANRNN--------------FTRSTQHFLLGKLKRMR----------------LRLSI 346
             |: |..::|.::              |.|.::....|.:..:|                .|.:.
Human   471 PRW-QTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAA 534

  Fly   347 LPRNSSAQSMV---------RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQ 402
            ..:..:...|:         :.::..|....::...:|.|:....|.|          |.|...|
Human   535 KEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFS----------AKVMADQ 589

  Fly   403 L--IPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFIL 465
            |  .||| .:..:.|..|       :|:|:..:|.::.|..:|:.|||....|..|.:..:|.::
Human   590 LRKPPSR-DQWSMTPQTV-------NAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVM 646

  Fly   466 GHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPRFQQE--------LGCLRRRF----------- 511
            ||||:|.||.:|..:          |:|.:..|.:|.|        ..|:..::
Human   647 GHELTHAFDDQGREY----------DKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLN 701

  Fly   512 GRKRY-EKFADASGLELAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSDKELLQAHD 575
            ||:.. |..||..||:.||:||....:...:..:.....:|..|.||..|||.:||.:....:|:
Human   702 GRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHE 766

  Fly   576 ------HGSDRKRVNDAVAHFEPFREAFSC 599
                  |...|.||...:::...|...|.|
Human   767 GLVTDPHSPARFRVLGTLSNSRDFLRHFGC 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	143/699 (20%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	143/699 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010