DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and ece1

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	782	Identity:	159/782 - (20%)
Similarity:	276/782 - (35%)	Gaps:	247/782 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HFKLRLLELIVGLLVV-----------QVKSHP---------------------QADPCQNFYKV 34
            |.:.:|:.|:..|.|.           ..:|||                     ..||||:||..
Zfish    46 HSERKLVVLVCALSVALFICIVSLGLHYKESHPGLCLSEPCVSVASAVLGSLDRSVDPCQDFYNF 110

  Fly    35 ACGNWSASHATDSYES----FMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYTAC------ 89
            |||.|...:.....:|    |.:..::| ...:.:||:|..........|:.:.:|.||
Zfish   111 ACGGWMRKNPLPEGKSRWGPFSNLWEHN-MAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKI 174

  Fly    90 ----RKPLSQD--------------------QVLRILEHLIVMENIQNEELSVGLTAAFRLQVLI 130
                .||| ||                    :|||     ||..|.:....       |.:.|..
Zfish   175 EELGAKPL-QDLINQTGGWGLKGPWEKDNFQEVLR-----IVSANFRTSPF-------FTVFVST 226

  Fly   131 DLNDSNTYDIWKQL------MSHRKHWDPNTTNREPL--------------------TREMFDKL 169
            |...||:..|  |:      :..|:::...|.|.:.|                    :::|.:::
Zfish   227 DSKSSNSNII--QVDQSGLGLPSREYYLNKTANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEI 289

  Fly   170 ---WASLPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYEN 231
               ..:|..|..|       ::...:|:.:.|     ...:.:|.|..|....||:
Zfish   290 IEFETTLANITVP-------QVERRDEEKIYY-----KIQAKELATLAPAIDWMPF--------- 333

  Fly   232 LSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPR 296
            ||.:...:::..:|.::.|....|:.|:|.:|            ..::.:|::.....|.:
Zfish   334 LSSVFAPVELNNSEPVVVYAKEYLQKVSELIS------------NTNKSVLNNYMIMKVVR---- 382

  Fly   297 LKEEPVLQDIFAELKQRFGQKLLANRNNF----------TRSTQHFLLGKLKRMRLRLSILPRNS 351
             |...:|...|.:.:|||.:.:...:.:.          |.|...|.||.|    ...:....:|
Zfish   383 -KMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTDSALGFALGAL----FVKATFSEDS 442

  Fly   352 SA--QSMVRRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQ-LWAIVFGRQLI--PSRISK- 410
            .|  :.||..|:..:.|.....|      .:.....::.|:.|. ::.:|...:.|  |..:.|
Zfish   443 KAFVEDMVSEIKWAFEDSLKTVS------WMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKV 501

  Fly   411 -------SDLYPTQVRGYGTYA------------------------SAFYIVKQNMLIVPLSLLE 444
                   ||||...|..|..::                        :|:|...:|.:::|..:.:
Zfish   502 FNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQ 566

  Fly   445 PPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHG-----VGSSAVDRELDRNPRFQQEL 504
            .|||.|..|..:.:..:|.::||||:|.||.:|..:...|     ..:|:|:       .||.:.
Zfish   567 APFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVE-------AFQHQT 624

  Fly   505 GCLRRRFGRKRY------------EKFADASGLELAYSAYFDTAQTDHKRNRSAEEL----VTQK 553
            .|:..::.....            |..||..||..||.||.:..    |:|.....|    :...
Zfish   625 QCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWI----KKNGEEASLPALGMNNH 685

  Fly   554 QQFFHNFAQFFCSDKELLQAHD------HGSDRKRVNDAVAHFEPFREAFSC---GPSPRRRQCR 609
            |.||..|||.:||.:....:|:      |...|.||...:::...|.|.|.|   .|...:|:|.
Zfish   686 QLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCE 750

  Fly   610 LY 611
            |:
Zfish   751 LW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	147/715 (21%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	150/732 (20%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	149/723 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010