DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and PHEX

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	770	Identity:	168/770 - (21%)
Similarity:	286/770 - (37%)	Gaps:	245/770 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ELIVGLLVVQVKSHPQADPCQNFYKVACGNWSASHA----TDSYESFMDRLDYNYQEKLADLLD- 68
            |.|.....:..|.:...|||.||::.||..|.:::.    ..||..: ..|.:|...||.:||:
Human    58 ECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVY-PWLRHNVDLKLKELLEK 121

  Fly    69 --NEREDDEPHFLQQLRNFYTAC----------RKPLSQDQVLR-------ILEHLIVMENIQNE 114
              :.|.|.|.  :|:.:..|::|          .|||.  .:||       :||..|..|.:.:|
Human   122 SISRRRDTEA--IQKAKILYSSCMNEKAIEKADAKPLL--HILRHSPFRWPVLESNIGPEGVWSE 182

  Fly   115 -ELSVGLTAA-----------FRLQVLIDLNDSNTY----DIWKQLMSHRKHWDPNTTN----RE 159
             :.|:..|.|           .||.|..|...||.:    |.....::.|:.:..|:|.    |:
Human   183 RKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRD 247

  Fly   160 PLTREMFD--------------------KLWASLPKIPFPFKE------YYWRELSELE------ 192
            .|.:.|.|                    :|...:.:|..|.:.      |....:|||.
Human   248 ALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQF 312

  Fly   193 ------EKIMS---YGSEDDGFDSGDLVTRIPPF---------------------WMMPWPNGNI 227
                  :|::.   |....|...|.::|.|:|.:                     |.|.:..
Human   313 DWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSR--- 374

  Fly   228 TYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVST--ESWHIDRDQCAEQSRQILSHPAAWLV 290
             ..|||:.            ..|.::....|.:|.:|  ..|    |:|..            .:
Human   375 -IPNLSRR------------FQYRWLEFSRVIQGTTTLLPQW----DKCVN------------FI 410

  Fly   291 EKNHPRLKEEPVLQDIFAELKQRFGQKLL-----ANRNNFTRSTQHFLLGKLKRMRLRLSILPRN 350
            |...|.:..:..:...|.|.|:...::|:     |..:...:..:....|..::.:
Human   411 ESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAK--------- 466

  Fly   351 SSAQSMVRRI---ERHYRDVHMN---------ASDYFGNLHIGLNHSRSHKKYAQ---LWAIVFG 400
            ..|::::.::   |....|.|:|         .:|||||:      .::.|..||   .|.
Human   467 EKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNV------LQTRKYLAQSDFFWL---- 521

  Fly   401 RQLIPSRISKSDLY--PTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQ-PSILTYSALG 462
            |:.:|    |::.:  ||.|       :|||....|.:..|...|:.||:...: |..|:|.|:|
Human   522 RKAVP----KTEWFTNPTTV-------NAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIG 575

  Fly   463 FILGHELSHGFDSEGMTFSSHGVGSSAVDRELD------RNPRFQQELGCLRRRFG--------- 512
            .|:|||.:||||:.|..:..:|        .||      ...:|:::..|:..::.
Human   576 VIVGHEFTHGFDNNGRKYDKNG--------NLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGL 632

  Fly   513 -----RKRYEKFADASGLELAYSAYFDTAQTDHKRNRSAEE------LVTQKQQFFHNFAQFFCS 566
                 |...|..||..||..|:.||   .:..:.|.:..||      ..|..|.||.::|...|:
Human   633 NVKGKRTLGENIADNGGLREAFRAY---RKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCN 694

  Fly   567 D------KELLQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSPRRRQ----CRLY 611
            .      :|.:|...|...:.|||.|:::||.|::||:|.|:....:    |||:
Human   695 SYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	161/738 (22%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	162/750 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010