Protein Alignment frma and PHEX

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 168/770 - (21%)
• Similarity: 286/770 - (37%)
• Gaps: 245/770 - (31%)

  Fly     9 ELIVGLLVVQVKSHPQADPCQNFYKVACGNWSASHA----TDSYESFMDRLDYNYQEKLADLLD- 68
            |.|.....:..|.:...|||.||::.||..|.:::.    ..||..: ..|.:|...||.:||:
Human    58 ECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVY-PWLRHNVDLKLKELLEK 121

  Fly    69 --NEREDDEPHFLQQLRNFYTAC----------RKPLSQDQVLR-------ILEHLIVMENIQNE 114
              :.|.|.|.  :|:.:..|::|          .|||.  .:||       :||..|..|.:.:|
Human   122 SISRRRDTEA--IQKAKILYSSCMNEKAIEKADAKPLL--HILRHSPFRWPVLESNIGPEGVWSE 182

  Fly   115 -ELSVGLTAA-----------FRLQVLIDLNDSNTY----DIWKQLMSHRKHWDPNTTN----RE 159
             :.|:..|.|           .||.|..|...||.:    |.....::.|:.:..|:|.    |:
Human   183 RKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRD 247

  Fly   160 PLTREMFD--------------------KLWASLPKIPFPFKE------YYWRELSELE------ 192
            .|.:.|.|                    :|...:.:|..|.:.      |....:|||.
Human   248 ALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQF 312

  Fly   193 ------EKIMS---YGSEDDGFDSGDLVTRIPPF---------------------WMMPWPNGNI 227
                  :|::.   |....|...|.::|.|:|.:                     |.|.:..
Human   313 DWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSR--- 374

  Fly   228 TYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVST--ESWHIDRDQCAEQSRQILSHPAAWLV 290
             ..|||:.            ..|.::....|.:|.:|  ..|    |:|..            .:
Human   375 -IPNLSRR------------FQYRWLEFSRVIQGTTTLLPQW----DKCVN------------FI 410

  Fly   291 EKNHPRLKEEPVLQDIFAELKQRFGQKLL-----ANRNNFTRSTQHFLLGKLKRMRLRLSILPRN 350
            |...|.:..:..:...|.|.|:...::|:     |..:...:..:....|..::.:
Human   411 ESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAK--------- 466

  Fly   351 SSAQSMVRRI---ERHYRDVHMN---------ASDYFGNLHIGLNHSRSHKKYAQ---LWAIVFG 400
            ..|::::.::   |....|.|:|         .:|||||:      .::.|..||   .|.
Human   467 EKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNV------LQTRKYLAQSDFFWL---- 521

  Fly   401 RQLIPSRISKSDLY--PTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQ-PSILTYSALG 462
            |:.:|    |::.:  ||.|       :|||....|.:..|...|:.||:...: |..|:|.|:|
Human   522 RKAVP----KTEWFTNPTTV-------NAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIG 575

  Fly   463 FILGHELSHGFDSEGMTFSSHGVGSSAVDRELD------RNPRFQQELGCLRRRFG--------- 512
            .|:|||.:||||:.|..:..:|        .||      ...:|:::..|:..::.
Human   576 VIVGHEFTHGFDNNGRKYDKNG--------NLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGL 632

  Fly   513 -----RKRYEKFADASGLELAYSAYFDTAQTDHKRNRSAEE------LVTQKQQFFHNFAQFFCS 566
                 |...|..||..||..|:.||   .:..:.|.:..||      ..|..|.||.::|...|:
Human   633 NVKGKRTLGENIADNGGLREAFRAY---RKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCN 694

  Fly   567 D------KELLQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSPRRRQ----CRLY 611
            .      :|.:|...|...:.|||.|:::||.|::||:|.|:....:    |||:
Human   695 SYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	161/738 (22%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	162/743 (22%)