DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and Nep5

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	154/798 - (19%)
Similarity:	271/798 - (33%)	Gaps:	274/798 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QADPCQNFYKVACGNWSASH-ATDSYESFMDRLDYNYQEKLADLLDNERE-------DDEPHFLQ 80
            |.|||::||:..||.|:..| ..||..|    .|: ::|:.|.::...||       ..||..:.
  Fly   149 QTDPCEDFYQFTCGRWANEHPRPDSVTS----NDW-FRERQAHIMRVVREFLRSNITKSEPEAVG 208

  Fly    81 QLRNFYTACRKPLSQDQVLRILEHLI---------VMENIQNEELSVGLTAAFR--------LQV 128
            :.:..|.||......|:  |.||.||         |:.:..|..|..|...|..        ||.
  Fly   209 KAKTMYRACMDTKLLDK--RDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQS 271

  Fly   129 LIDLNDSNTYDIWKQLMSHRKHWDP--NTTNREPLTREMFDKLWASLPKIPFPF-KEYYWRELSE 190
            ::.:....|.|:   ::......||  .|.||..|.....|.        .||| .:...:.|.:
  Fly   272 IVSIKQHLTMDL---IIGFDVFPDPFNRTINRIALGTPETDS--------AFPFNNDDSHKMLRK 325

  Fly   191 LEEKIMSYGSEDDGFDSGD---------------------------------------------- 209
            :..|.:...:.||..||.|
  Fly   326 IHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATL 390

  Fly   210 ----------------------------------------------------LVTRIPPFWM--- 219
                                                                :..:..|.|:
  Fly   391 GITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYM 455

  Fly   220 --------------------MPWPNGNITYENLSQMAHWLDIKANEFILTYI------------- 251
                                :.....:|||  |..:..:||......|.:|:
  Fly   456 ELILKGTRHAGNIQMTQNLTIITSQADITY--LQNIVEYLDDTPASHIESYLFLSTIEELVLHTS 518

  Fly   252 ---------YMRLKLVAEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIF 307
                     |||:.:..||.:..|.:     ||.....:|....::::.......::.|.::.:.
  Fly   519 SSMRLLHSEYMRVAIGTEGSTPRSLY-----CANGVNSLLGMAVSYVLADADFTKEKLPKVERML 578

  Fly   308 AELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILP--RNSSAQSMVRRIERHYRDVHMN 370
            :::::.| .:|:.:.:....:|:...:.|...|:..:...|  ||:|.      :..:|....:|
  Fly   579 SDIRRSF-DRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASV------LNAYYEGAEVN 636

  Fly   371 ASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYAS---AFYIVK 432
            ||.:..|| :...|          |.::       .::::.| .|..: |:.|..|   ||:..:
  Fly   637 ASTHLENL-MDFVH----------WQMM-------DKLNEMD-KPEPI-GWATSPSNVNAFHTFQ 681

  Fly   433 QNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHG-----VGSSAVDR 492
            .|.:.||:::|:.|||..|..: |.|.::|.||||||:||||..|..|...|     ..:..:|.
  Fly   682 SNAITVPIAILQYPFYDLGLEA-LNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDE 745

  Fly   493 ELDRNPRFQQELGCLRRRFGRKRY----------------EKFADASGLELAYSAY-FDTAQTDH 540
            .::|...|.::.         .||                |..||..|:..|:.|| ....:...
  Fly   746 YVNRTECFVEQY---------SRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGR 801

  Fly   541 KRNR-SAEELVTQKQQFFHNFAQFFC-------SDKELLQAHDHGSDRKRVNDAVAHFEPFREAF 597
            :|:: ...|..:.:|.||.:|...:|       |...|..:|..|  :.|:...:::.|.|...|
  Fly   802 ERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPG--QMRLRGVLSNSEEFARTF 864

  Fly   598 SCG----PSPRRRQCRLY 611
            .|.    .:|.:.:||::
  Fly   865 KCARGTPMNPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	150/785 (19%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	154/796 (19%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	151/792 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010