DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and MME

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	744	Identity:	154/744 - (20%)
Similarity:	271/744 - (36%)	Gaps:	229/744 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPCQNFYKVACGNWSASHA---TDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYT 87
            :||.:|:|.|||.|...:.   |.|.....|.|....:..|.|:|...:.:|.. .:|:.:..|.
Human    78 EPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIV-AVQKAKALYR 141

  Fly    88 ACRKPLSQDQ-----VLRILEHL----IVMENIQN--------EELSVGLTAAFRLQVLIDL--- 132
            :|....:.|.     :|::|..:    :..||.:.        |:....|.:.:..:|||:|
Human   142 SCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVG 206

  Fly   133 -NDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYY------------ 184
             :|.|:       ::|..|.|.                    |::..|.::||
Human   207 TDDKNS-------VNHVIHIDQ--------------------PRLGLPSRDYYECTGIYKEACTA 244

  Fly   185 ----------------------------WRELSELEEKIMSYGSEDDGFDSGD------------ 209
                                        ..::.|||::|.:..::.:  |..|
Human   245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPE--DRNDPMLLYNKMTLAQ 307

  Fly   210 ------LVTRIPPF-WMMPWPNGNITYENLSQMAHWLDIKANEFILTYI--YM-RLKLVAEGVST 264
                  |.....|| |:      |.|.|.:|.:.  :.|...|.::.|.  |: :||.:....|.
Human   308 IQNNFSLEINGKPFSWL------NFTNEIMSTVN--ISITNEEDVVVYAPEYLTKLKPILTKYSA 364

  Fly   265 E------SWHIDRDQCAEQSRQ--------------ILSHPAAWL---------VEKNHPRL--- 297
            .      ||....|..:..||.              ..|..|.|.         :|....||
Human   365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVE 429

  Fly   298 -----KEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSSAQSMV 357
                 :.:.|::|:.|::::.|.|.|    ::.|.....   .|.:.....|:|..|......:|
Human   430 AAFAGESKHVVEDLIAQIREVFIQTL----DDLTWMDAE---TKKRAEEKALAIKERIGYPDDIV 487

  Fly   358 ---RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQL--IPSRISKSDLYPTQ 417
               .::...|.:::....:||.|:...|..|:|             :||  :..::.|.:    .
Human   488 SNDNKLNNEYLELNYKEDEYFENIIQNLKFSQS-------------KQLKKLREKVDKDE----W 535

  Fly   418 VRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSS 482
            :.| ....:|||...:|.::.|..:|:|||::..|.:.|.|..:|.::|||::||||..|..|:.
Human   536 ISG-AAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNK 599

  Fly   483 HGVGSSAVDRELDRN-PRFQQELGCLRRRFGRKRY---------------EKFADASGLELAYSA 531
            .|   ..||....:: ..|:::..|:..::|...:               |..||..||..||.|
Human   600 DG---DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661

  Fly   532 YFDTAQTDHKRNRSAEEL----VTQKQQFFHNFAQFFCSD------KELLQAHDHGSDRKRVNDA 586
            |    |...|:|...:.|    :..||.||.||||.:|..      ...::...|.....|:...
Human   662 Y----QNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGT 722

  Fly   587 VAHFEPFREAFSCGP----SPRRRQCRLY 611
            :.:...|.|||.|..    :|.:: ||::
Human   723 LQNSAEFSEAFHCRKNSYMNPEKK-CRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	151/728 (21%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	152/739 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010