Protein Alignment frma and Nep2

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 152/738 - (20%)
• Similarity: 274/738 - (37%)
• Gaps: 208/738 - (28%)

  Fly    20 KSHPQADPCQNFYKVACGNWSASH-------ATDSYESFMDRLDYNYQEKLADLLDNEREDDEP- 76
            |..|:.:||.|||:.|||.:....       :..::....|:|    ||:|.|::..||.:.||
  Fly    99 KMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKL----QEQLKDIITAERPETEPK 159

  Fly    77 HFLQQLRN-FYTACR-----KPLSQDQVLRILEHL----IVMENIQN--------EELSVGLTAA 123
            ||  :|.| .|.||.     :.|..:.:.|:.|.|    ::..:..|        |::....||.
  Fly   160 HF--RLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAG 222

  Fly   124 FRLQVLIDLNDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKE-----Y 183
            |.:..:||      :.|...|.:..|.......:...|:||...|          .|.|     |
  Fly   223 FSMDYIID------FSIGVDLQNSTKRLIDLDQSSLALSREYLVK----------GFNETLVTAY 271

  Fly   184 YW------------RELSELEEKI----------MSYGSEDDGFDSGDLVTRIP-------PFWM 219
            |.            |:|::.|..:          :|:.:|.....|.....|.|       |:
  Fly   272 YKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQLQAAYPY-- 334

  Fly   220 MPW--------PNG-NITYE---NLSQMAHWLDI------KANEFILTYIYMRLKLVAEGVSTES 266
            :.|        |.| |:..:   |||..:.:.|:      .....|..|::.|:...:.|..:|.
  Fly   335 VQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEE 399

  Fly   267 WHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKE---------EPVLQDIFAEL---------KQR 313
            :         :.||:....|....::...|.||         :.|.:|.|..|         .:.
  Fly   400 F---------RKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKH 455

  Fly   314 FGQKLLAN---RNNFTRSTQHFLLGKL--------KRMRLRL-SILPRNSSAQSMV--RRIERHY 364
            |.:...||   ..|..|:..:.:|.::        |..:|:| |:.........|:  .::..:|
  Fly   456 FHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYY 520

  Fly   365 RDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFG------RQLIPSRISKSDLYPTQVR-GYG 422
            ..:.::...||.:. :|:|              :||      :..:|  ::|:|    .|| ...
  Fly   521 AKLDIDPDKYFESF-LGMN--------------IFGTDYSFNKLRLP--VNKTD----WVRHARP 564

  Fly   423 TYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGS 487
            ...:|||...:|.:..|..:|:..|:...:|..:.:.|:|:::|||::||||.:|..|...|
  Fly   565 AIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKG--- 626

  Fly   488 SAVDREL------DRNPRFQQELGCLRRRFG--------------RKRYEKFADASGLELAYSAY 532
                 .|      |....:..:..|:..::|              ..:.|..||..|::.:|.||
  Fly   627 -----NLRDWWHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAY 686

  Fly   533 FDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSD--KELLQAH----DHGSDRKRVNDAVAHFE 591
            ...|:......:......|.:|.|:....|.:|:.  ||.|:..    .|.....||..::::.:
  Fly   687 RRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMK 751

  Fly   592 PFREAFSC---GPSPRRRQCRLY 611
            .|.:.|.|   .|....::|.::
  Fly   752 DFAKDFHCPEGSPMNPVQKCEVW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	148/721 (21%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	149/729 (20%)