DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and KEL

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	764	Identity:	154/764 - (20%)
Similarity:	269/764 - (35%)	Gaps:	246/764 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVGLLV-----------------------VQVKSHPQAD------PCQNFYKVACGNWSASHAT 45
            ||:|||:                       :.::.|..|.      ||.:|:..|||     .|.
Human    65 LILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACG-----RAK 124

  Fly    46 DSYESFMDRLDYNYQEKLADLLDNER-----EDDEPHFLQQLRNFYTACRK----------PLSQ 95
            ::..||.:....| :.:|..:|:.:.     ..:|..|     .||.:|..          ||.|
Human   125 ETNNSFQELATKN-KNRLRRILEVQNSWHPGSGEEKAF-----QFYNSCMDTLAIEAAGTGPLRQ 183

  Fly    96 DQVLRILEHLIVMENIQNEELSVGLTAAFRLQVLIDLNDSNTYDIWKQLMSHRKHW--------- 151
                       |:|.:....:|...|:         ||.:.|.   :.|||...|:
Human   184 -----------VIEELGGWRISGKWTS---------LNFNRTL---RLLMSQYGHFPFFRAYLGP 225

  Fly   152 ---DPNTTNRE--------PLTREMFDKLWASLPKIPFPFKEY--YWRELSEL----EEKIMSYG 199
               .|:|...:        ||.::...|::|.:      |:||  |..:|..|    ..|:..:.
Human   226 HPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQI------FREYLTYLNQLGTLLGGDPSKVQEHS 284

  Fly   200 SEDDGFDSG-----------------------DLVTRIPPFWMMPW--------------PNGNI 227
            |......|.                       |.:..:.|  .:.|              |:.::
Human   285 SLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAP--AIDWLSCLQATFTPMSLSPSQSL 347

  Fly   228 T------YENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQILSHP- 285
            .      .:|:||:...:.:|..:|:.:::.:.|.:.........:...|.:.:::.|::...|
Human   348 VVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPP 412

  Fly   286 ----AAWL--VEKNHPRLKEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLK-RMRLR 343
                ..|:  ||:.....  ||.|..:|  :::.||..        |||....|...:: .:..|
Human   413 MPARPRWMKCVEETGTFF--EPTLAALF--VREAFGPS--------TRSAAMKLFTAIRDALITR 465

  Fly   344 LSILP-----RNSSAQSMVRRIERHYRDVHMNASDY----------FGNLHIGLNHSRSHKKYAQ 393
            |..||     ..:.||..|.:::     |.|.||::          :.::.:|.:.
Human   466 LRNLPWMNEETQNMAQDKVAQLQ-----VEMGASEWALKPELARQEYNDIQLGSSF--------- 516

  Fly   394 LWAIVFGRQLIPSRISKSDLYPTQVRGYGTY---ASAFYIVKQNMLIVPLSLLEPPFYTHGQPSI 455
            |.:::...:.:.:||.:|.|.|.....:...   .:|:|.|..::::.|..||:|||:..|.|..
Human   517 LQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRA 581

  Fly   456 LTYSALGFILGHELSHGFDS---EGMTFSSHGVGSSAVDRELDRNPRFQQELGCLRRRF------ 511
            :.:.|.|.|:.|||.|.|..   .|        |..|.|     |...|:...||:|.:
Human   582 VNFGAAGSIMAHELLHIFYQLLLPG--------GCLACD-----NHALQEAHLCLKRHYAAFPLP 633

  Fly   512 GRKRY-------EKFADASGLELAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSDKE 569
            .|..:       |..||..||.:|..||.......|.........::.:|.||.::||..|....
Human   634 SRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPS 698

  Fly   570 LLQAHD-HGSDRKRVNDAVAHFEPFREAFSC------GPSPRRRQCRLY 611
            ...:|| |.....||:..::....|...|.|      .||.|   |:|:
Human   699 PQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSR---CQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	143/714 (20%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	146/721 (20%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	145/716 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940