DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and Nepl10

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_610787.1	Gene:	Nepl10 / 36366	FlyBaseID:	FBgn0033742	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	628	Identity:	161/628 - (25%)
Similarity:	277/628 - (44%)	Gaps:	108/628 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PCQNFYKVACGNW-SASHATDSYESFMDRLDYNYQEKLADLLDN---EREDDEPHFLQQLRNFYT 87
            ||.||:..|||.: |||...|::|    |::..:...:.:.:::   |.:...|..::|:|.:|.
  Fly    42 PCTNFWNFACGRFSSASKYVDNFE----RVEDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYK 102

  Fly    88 ACRK--------PLSQDQVLRILEHLIVMENIQNEELSVGLTAAFRLQVLIDL--NDSNTYDIWK 142
            ||::        |..::.|.:.:.|       ..:.|..||...| :...:|:  |||..:.|..
  Fly   103 ACKEDTRKLHGNPRPEELVNQWILH-------PKKFLVYGLNGVF-IDERVDVAANDSMRWVIQL 159

  Fly   143 QLMSHRKHWDPNTTNREPLTR-----EMFDKLWASLPKIPFPFK----------EY---YWRELS 189
            ::        |:..:|....|     .::::.|.|:..:....|          ||   |....|
  Fly   160 RM--------PDPADRYSDRRVLQLMRLYEEAWYSMGVVKLVEKMHQLQDKYRAEYPVVYTWSFS 216

  Fly   190 ELEEKI---MSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFILTYI 251
            ||.::|   .|:..|..|      |......:.:.:...::.|  |.:....|...|:|...|||
  Fly   217 ELRQEIPIPHSFFIELLG------VNHTEELYHLTFEVSDVEY--LRECFRCLRDFASEPKDTYI 273

  Fly   252 YMRLKLVAEGVSTESWHIDRD--QCAEQSRQILSHPAAWLVEKNHPRLKEEPV--LQDIFAELKQ 312
            ..|..::.|    ||...:|:  .|....|..|.....::.::...:.:||..  :.:|.:.||.
  Fly   274 RARQYVLVE----ESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKA 334

  Fly   313 RFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSSAQSMVRRIERHYRDVHMNASDYFGN 377
            .|||.|.|||...|.:...::..||:.:::::..||...|.:.    ...||...:.:|:::..|
  Fly   335 AFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKSPEF----YNNHYGSANFSATNFLAN 395

  Fly   378 LHIGLNHSRSHKKYAQLWAIVFGRQL----IPSRISKSDL----YPTQVRGYGTYASAFYIVKQN 434
            |               |.|.....:|    :.:|.|:.||    ....||...|  |.||..::|
  Fly   396 L---------------LEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRKART--SPFYENERN 443

  Fly   435 MLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPR 499
            .:.||:..|:.|.:.|.:.:|..:|.||.:||||::|.|:.||:.|.:.| ..|.|..|:..:..
  Fly   444 TITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAG-NESPVGLEIRESKP 507

  Fly   500 FQQELGCLRRRFGRKRYEKFADASGLELAYSAYF----DTAQTDHKRNRSAEELVTQKQQFFHNF 560
            |:..:.|...:......|:.||.:||:|||.|:|    |:.|.:: |..:.|:..|..|.|..::
  Fly   508 FRDAIKCAEEQPFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEY-RPYAFEQEFTAPQLFHLSY 571

  Fly   561 AQFFCSDKELLQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSP 603
            |||||.....:.|||.  |.:|||.:|.:...|...|:|..||
  Fly   572 AQFFCGSLPPVIAHDR--DDERVNVSVGNLRQFAYDFNCETSP 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	159/624 (25%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:301352	158/622 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006719
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010