DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and Mmel1

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	151/740 - (20%)
Similarity:	265/740 - (35%)	Gaps:	227/740 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PCQNFYKVACGNWSASHA---TDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYTA 88
            ||.|||:.|||.|...|.   |:|..|..|.|....:..|..:|::......| .:::.:..|.:
  Rat   107 PCDNFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSSVQHRP-AVEKAKTLYRS 170

  Fly    89 CR-----KPLSQDQVLRILEHL----IVMENIQNE----------ELSVGLTAAFRLQVLIDLND 134
            |.     :....:.:|.:|:.:    :.|:. .||          :|:| |.:.|..:|||||
  Rat   171 CMNQSVIEKRDSEPLLNVLDMIGGWPVAMDK-WNETMGPKWELERQLAV-LNSQFNRRVLIDL-- 231

  Fly   135 SNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYWRELS-ELEEKIMSY 198
                .||....:..:|                 .::...|.:..|.:|||::|.| .:.|..:.:
  Rat   232 ----FIWNDDQNSSRH-----------------VIYIDQPTLGMPSREYYFKEDSHRVREAYLQF 275

  Fly   199 GSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFI-------LTYIYMRLK 256
            .:        .:.|.:.....:|... ::..|.::|:.|.....||..:       :|.:|.|:.
  Rat   276 MT--------SVATMLRRDLNLPGET-DLVQEEMAQVLHLETHLANATVPQEKRHDVTALYHRMG 331

  Fly   257 L--VAE--GVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIF---------- 307
            |  :.|  |:...:|.: ..|....|.|:...|...:|....|.|:....:.|:|
  Rat   332 LEELQERFGLKGFNWTL-FIQNVLSSVQVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLV 395

  Fly   308 --------AELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSSAQSMV------- 357
                    ..|.|||.:..:..|.....:|       ::.:|.|..:...||:.:|.|
  Rat   396 WRLVLDRIGSLSQRFKEARVDYRKALYGTT-------MEEVRWRECVSYVNSNMESAVGSLYIKR 453

  Fly   358 -------------------------------------------------------------RRIE 361
                                                                         |.::
  Rat   454 AFSKDSKSIVSELIEKIRSVFVDNLDELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLD 518

  Fly   362 RHYRDVHMNASDYFGNLHIGL-----NHSRSHKKYAQ-----LWAIVFGRQLIPSRISKSDLYPT 416
            ..|..:..:...||.|   ||     |..||.||..:     ||  :.|..::
  Rat   519 EEYSSLTFSEDLYFEN---GLQNLKNNAQRSLKKLREKVDQNLW--IIGAAVV------------ 566

  Fly   417 QVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFS 481
                     :|||...:|:::.|..:|:|||::..||..|.:..:|.::|||::||||..|..|.
  Rat   567 ---------NAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFD 622

  Fly   482 SHGVGSSAVDRELDRNPR-FQQELGCLRRRFGRKRY---------------EKFADASGLELAYS 530
            .:|   :.:|...:.:.| |:|:..|:..::....:               |..||..|:..||.
  Rat   623 KNG---NMLDWWSNFSARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYK 684

  Fly   531 AYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSDK------ELLQAHDHGSDRKRVNDAVAH 589
            ||........:..|.....:|..|.||.|:||.:|...      :.::...|...:.||..::.:
  Rat   685 AYLQWLAEGGRDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQN 749

  Fly   590 FEPFREAFSC---GPSPRRRQCRLY 611
            ...|.|||.|   .|.....:||::
  Rat   750 LPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	148/728 (20%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	149/736 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010