Protein Alignment frma and Mmel1

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 750
• Identity: 157/750 - (20%)
• Similarity: 266/750 - (35%)
• Gaps: 244/750 - (32%)

  Fly    26 DPCQNFYKVACGNWSASHA---TDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFYT 87
            :||:|||:.|||.|...|.   |:|..|..|.|....:..|..:|::......| .:::.:..|.
Mouse    97 NPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSTSQHRP-AVEKAKTLYR 160

  Fly    88 AC----------RKPLSQDQVLRILEHLIVMENIQNE----------ELSVGLTAAFRLQVLIDL 132
            :|          .:||.  .||:::....|..:..||          :|:| |.:.|..:|||||
Mouse   161 SCMNQSVIEKRDSEPLL--SVLKMVGGWPVAMDKWNETMGLKWELERQLAV-LNSQFNRRVLIDL 222

  Fly   133 NDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYWRE---------L 188
                  .||....:..:|                 .::...|.:..|.:|||::|         .
Mouse   223 ------FIWNDDQNSSRH-----------------VIYIDQPTLGMPSREYYFQEDNNHKVRKAY 264

  Fly   189 SELEEKIMSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIK---ANEFI--- 247
            .|....:.:...:|........:.|                   .:||..|:::   ||..:
Mouse   265 LEFMTSVATMLRKDQNLSKESAMVR-------------------EEMAEVLELETHLANATVPQE 310

  Fly   248 ----LTYIYMRLKLV----AEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQ 304
                :|.:|.|:.|:    ..|:...:|.: ..|....|.::...|...:|....|.|:.   |:
Mouse   311 KRHDVTALYHRMDLMELQERFGLKGFNWTL-FIQNVLSSVEVELFPDEEVVVYGIPYLEN---LE 371

  Fly   305 DI---------------------FAELKQRFGQKLLANRN----------------NFTRSTQHF 332
            ||                     ...|.|||.:..:..|.                ::..|....
Mouse   372 DIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMES 436

  Fly   333 LLGKL--KRMRLRLSILPRNSSAQSMVRRI---------ERHYRDVH---------MNASDYFG- 376
            .:|.|  ||...:.|    .|:.:.::.:|         |.::.|..         ||..:..|
Mouse   437 AVGSLYIKRAFSKDS----KSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIGY 497

  Fly   377 --------NLHI-----------------GL-----NHSRSHKKYAQ-----LWAIVFGRQLIPS 406
                    |.|:                 ||     |..||.||..:     ||  :.|..::
Mouse   498 PDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKLREKVDQNLW--IIGAAVV-- 558

  Fly   407 RISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSH 471
                               :|||...:|.::.|..:|:|||::..||..|.:..:|.::|||::|
Mouse   559 -------------------NAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITH 604

  Fly   472 GFDSEGMTFSSHGVGSSAVDRELDRNPR-FQQELGCLRRRFGRKRY---------------EKFA 520
            |||..|..|..:|   :.:|...:.:.| |||:..|:..::|...:               |..|
Mouse   605 GFDDNGRNFDKNG---NMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLGENIA 666

  Fly   521 DASGLELAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSD------KELLQAHDHGSD 579
            |..|:..||.||........|..|.....:|..|.||.|:||.:|..      .:.::...|...
Mouse   667 DNGGVRQAYKAYLRWLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPL 731

  Fly   580 RKRVNDAVAHFEPFREAFSC---GPSPRRRQCRLY 611
            :.||..::.:...|.|||.|   .|....::||::
Mouse   732 KYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	154/738 (21%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	155/746 (21%)