DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and Mme

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	157/749 - (20%)
Similarity:	271/749 - (36%)	Gaps:	237/749 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ADPCQNFYKVACGNWSASHA---TDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFY 86
            |:||.:|:|.|||.|...:.   |.|..|..|.|....:..|.|:|...:.:|.. .:|:.:..|
  Rat    77 AEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIV-AVQKAKTLY 140

  Fly    87 TACRKPLSQD----QVLRILEHLIVMENI-------QNEELSVG-----------LTAAFRLQVL 129
            .:|....:.|    |.|     |.::.:|       ||.|.:.|           |.:.:..:||
  Rat   141 RSCINESAIDSRGGQPL-----LTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVL 200

  Fly   130 IDL----NDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYY------ 184
            |:.    :|.|:       ..|..|:|.                    |::..|.::||
  Rat   201 INFFVGTDDKNS-------TQHIIHFDQ--------------------PRLGLPSRDYYECTGIY 238

  Fly   185 ----------------------------------WRELSELEEKIMSYGSEDDGFDSGD------ 209
                                              ..::.|||::|.:..::.:  |..|
  Rat   239 KEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPE--DRNDPMLLYN 301

  Fly   210 ------------LVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFILTYI--YM-RLKLVA 259
                        |.....||   .|  .|.|.|.:|.:.  ::|:..|.::.|.  |: :||.:.
  Rat   302 KMTLAKLQNNFSLEINGKPF---SW--SNFTNEIMSTVN--INIQNEEEVVVYAPEYLTKLKPIL 359

  Fly   260 EGVSTE------SWHIDRDQCAEQSRQ--------------ILSHPAAWL---------VEKNHP 295
            ...|..      ||....|..:..||.              ..|..|.|.         :|....
  Rat   360 TKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVG 424

  Fly   296 RL--------KEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSS 352
            ||        :.:.|::|:.|::::.|.|.|    ::.|.....   .|.|.....|:|..|...
  Rat   425 RLYVEAAFAGESKHVVEDLIAQIREVFIQTL----DDLTWMDAE---TKKKAEEKALAIKERIGY 482

  Fly   353 AQSMV---RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQL--IPSRISKSD 412
            ...::   .::...|.:::....:||.|:...|..|:|             :||  :..::.|.:
  Rat   483 PDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQS-------------KQLKKLREKVDKDE 534

  Fly   413 LYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEG 477
                .:.| ....:|||...:|.::.|..:|:|||::..|.:.|.|..:|.::|||::||||..|
  Rat   535 ----WISG-AAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNG 594

  Fly   478 MTFSSHGVGSSAVDRELDRNP-RFQQELGCLRRRFGRKRY---------------EKFADASGLE 526
            ..|:..|   ..||....::. .|:.:..|:..::|...:               |..||..|:.
  Rat   595 RNFNKDG---DLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIG 656

  Fly   527 LAYSAYFDTAQTDHKRNRSAEEL----VTQKQQFFHNFAQFFCSD------KELLQAHDHGSDRK 581
            .||.||    |...|:|...:.|    :..||.||.||||.:|..      ...::...|.....
  Rat   657 QAYRAY----QNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNF 717

  Fly   582 RVNDAVAHFEPFREAFSCGP----SPRRRQCRLY 611
            |:...:.:...|.:||.|..    :|.|: ||::
  Rat   718 RIIGTLQNSAEFADAFHCRKNSYMNPERK-CRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	153/733 (21%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	154/743 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010