Protein Alignment frma and Ece1

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001356106.1
• Gene: Ece1 / 230857
• MGIID: 1101357
• Length: 769
• Species: Mus musculus
• Alignment Length: 749
• Identity: 163/749 - (21%)
• Similarity: 279/749 - (37%)
• Gaps: 255/749 - (34%)

  Fly    23 PQADPCQNFYKVACGNW-SASHATDSYE---SFMDRLDYNYQEKLADLLDN------EREDDEPH 77
            |..||||:|:..|||.| .|:...|.:.   :|.:..::| |..:..||:|      |.|
Mouse   116 PTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-QAVIKHLLENATASVSEAE----- 174

  Fly    78 FLQQLRNFYTAC----------RKPLSQDQVLRILEHL--------IVMENIQNEELSVGLTAAF 124
              ::.:.:|.||          .|||     :.::|.|        ...:|.| :.|.| :||.:
Mouse   175 --RKAQVYYRACMNETRIEELRAKPL-----MELIEKLGGWNITGPWAKDNFQ-DTLQV-VTAHY 230

  Fly   125 R------LQVLIDLNDSNTYDIWKQL------MSHRKHWDPNTTNREPLT--------------- 162
            |      :.|..|..:||:..|  |:      :..|.::...|.|.:.||
Mouse   231 RTSPFFSVYVSADSKNSNSNVI--QVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGG 293

  Fly   163 ----------REMFDKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPF 217
                      :::.| ...:|..|..|.::....||  :..|:          .:.:|.|..|..
Mouse   294 GDEDAIRPQMQQILD-FETALANITIPQEKRRDEEL--IYHKV----------TAAELQTLAPAI 345

  Fly   218 WMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQIL 282
            ..:|:.| .|.|.        ::|..:|.|:.|....|:.|:..::      :.|:|      :|
Mouse   346 NWLPFLN-TIFYP--------VEINESEPIVVYDKEYLRQVSTLIN------NTDKC------LL 389

  Fly   283 SHPAAW-LVEKNH--------------------------PRLK---------------------- 298
            ::...| ||.|..                          ||.|
Mouse   390 NNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKAT 454

  Fly   299 ----EEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRM--RLRLSILPRNSSAQSMV 357
                .:.:..:|..|:|:.|.:.|         ||       ||.|  ..|.|...:..:..:|:
Mouse   455 FAEDSKNIASEIIMEIKKAFEESL---------ST-------LKWMDEETRRSAKEKADAIYNMI 503

  Fly   358 ---------RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGR-QLIPSRISKSD 412
                     :.:::.:.|.......||.|.....|.|         |.:...: :..|:| .:..
Mouse   504 GYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFS---------WRVTADQLRKAPNR-DQWS 558

  Fly   413 LYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEG 477
            :.|..|       :|:|...:|.::.|..:|:.||||...|:.|.:..:|.::||||:|.||.:|
Mouse   559 MTPPMV-------NAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQG 616

  Fly   478 MTFSSHG-----VGSSAVDRELDRNPRFQQELGCLRRRF-----------GRKRY-EKFADASGL 525
            ..:...|     ..:|:|:       .|:|:..|:.:::           ||... |..||..||
Mouse   617 REYDKDGNLRPWWKNSSVE-------AFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGL 674

  Fly   526 ELAYSAYFDTAQTDHKRNRSAEEL----VTQKQQFFHNFAQFFCSDKELLQAHD------HGSDR 580
            :.||.||    |...|:|.:.:.|    :|..|.||..|||.:||.:....:|:      |...|
Mouse   675 KAAYRAY----QNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR 735

  Fly   581 KRVNDAVAHFEPFREAFSCGP-SPR--RRQCRLY 611
            .||..::::.:.|.|.|.|.| ||.  ..:|.::
Mouse   736 FRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	158/732 (22%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	161/743 (22%)