DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frma and ECE1

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	749	Identity:	161/749 - (21%)
Similarity:	275/749 - (36%)	Gaps:	255/749 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PQADPCQNFYKVACGNW-SASHATDSYE---SFMDRLDYNYQEKLADLLDN------EREDDEPH 77
            |..|||.:|:..|||.| .|:...|.:.   :|.:..::| |..:..||:|      |.|
Human   125 PTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-QAIIKHLLENSTASVSEAE----- 183

  Fly    78 FLQQLRNFYTAC----------RKPLSQDQVLRILEHL--------IVMENIQNEELSVGLTAAF 124
              ::.:.:|.||          .|||     :.::|.|        ...:|.| :.|.| :||.:
Human   184 --RKAQVYYRACMNETRIEELRAKPL-----MELIERLGGWNITGPWAKDNFQ-DTLQV-VTAHY 239

  Fly   125 R------LQVLIDLNDSNTYDIWKQL------MSHRKHWDPNTTNREPLT--------------- 162
            |      :.|..|..:||:..|  |:      :..|.::...|.|.:.||
Human   240 RTSPFFSVYVSADSKNSNSNVI--QVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGG 302

  Fly   163 ----------REMFDKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPF 217
                      :::.| ...:|..|..|.::....||  :..|:          .:.:|.|..|..
Human   303 GDEEAIRPQMQQILD-FETALANITIPQEKRRDEEL--IYHKV----------TAAELQTLAPAI 354

  Fly   218 WMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQIL 282
            ..:|:.| .|.|.        ::|..:|.|:.|....|:.::..::|      .|:|      :|
Human   355 NWLPFLN-TIFYP--------VEINESEPIVVYDKEYLEQISTLINT------TDRC------LL 398

  Fly   283 SHPAAW-LVEKNH--------------------------PRLK---------------------- 298
            ::...| ||.|..                          ||.|
Human   399 NNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKAT 463

  Fly   299 ----EEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRM--RLRLSILPRNSSAQSMV 357
                .:.:..:|..|:|:.|.:.|         ||       ||.|  ..|.|...:..:..:|:
Human   464 FAEDSKSIATEIILEIKKAFEESL---------ST-------LKWMDEETRKSAKEKADAIYNMI 512

  Fly   358 ---------RRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGR-QLIPSRISKSD 412
                     :.:::.:.|.......||.|.....|.|         |.:...: :..|:| .:..
Human   513 GYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFS---------WRVTADQLRKAPNR-DQWS 567

  Fly   413 LYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEG 477
            :.|..|       :|:|...:|.::.|..:|:.||||...|..|.:..:|.::||||:|.||.:|
Human   568 MTPPMV-------NAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 625

  Fly   478 MTFSSHG-----VGSSAVDRELDRNPRFQQELGCLRRRF-----------GRKRY-EKFADASGL 525
            ..:...|     ..:|:|:       .|:::..|:..::           ||... |..||..||
Human   626 REYDKDGNLRPWWKNSSVE-------AFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 683

  Fly   526 ELAYSAYFDTAQTDHKRNRSAEEL----VTQKQQFFHNFAQFFCSDKELLQAHD------HGSDR 580
            :.||.||    |...|:|.:...|    :|..|.||..|||.:||.:....:|:      |...|
Human   684 KAAYRAY----QNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR 744

  Fly   581 KRVNDAVAHFEPFREAFSCGP-SPRR--RQCRLY 611
            .||..::::.:.|.|.|.|.| ||..  .:|.::
Human   745 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	156/732 (21%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	159/738 (22%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	159/743 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010