Protein Alignment frma and nep-2

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 734
• Identity: 151/734 - (20%)
• Similarity: 283/734 - (38%)
• Gaps: 199/734 - (27%)

  Fly    16 VVQVKSHPQADPCQNFYKVACGNWSASH-------ATDSYESFMDRLDYNYQEKLADLLDNERED 73
            |:....:...|||.:||:.|||.|...|       :..::|:....|::    .|.:|||   |:
 Worm    64 VILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEF----ALKELLD---EN 121

  Fly    74 DEPHFLQ-----QLRNFYTACRKPLSQDQVL----RILEHLI------------VMENIQNEELS 117
            |||:..:     :.:.||..|   |::.::|    ...:.::            :..:...|.|.
 Worm   122 DEPYDYETSAVGKAKYFYNLC---LNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLY 183

  Fly   118 VGLTAAFRLQVL----IDLNDSNT------YDIWKQLMSHRKHWDPNTTNRE-----PLTREMF- 166
            ..:.|.|:...|    :..:|.|:      .| ..||....:.:.....|.|     .|.|::.
 Worm   184 ADMVAKFKADSLFKATVQPDDKNSQRHVLLID-QPQLNLFARDFYVAAENEERMAYLQLIRDVLI 247

  Fly   167 ----DKLWASLPKIPFPFKEYYWRELSELEEKIMSYGSEDD-GFDSGDLVTRI---------PPF 217
                |:..|:|..          :|:.:.|..:.:....|: ..|..:|.|:|         |.|
 Worm   248 LLDADRTRATLDA----------KEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPHF 302

  Fly   218 WMMPWP-------------NG-NITYENLSQMAHW-------LDIKA----NEFILTYI------ 251
               .||             || .||:::.:::..:       ||:..    |..|:.|:
 Worm   303 ---NWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFF 364

  Fly   252 ------------------YMRLKLVAEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLK 298
                              |..|.::  .|....||    .|..:...::....:.:..|||...:
 Worm   365 KTMLRDLPDPFALTIFKFYKTLNIM--NVQKVRWH----GCVTRINSLMPMATSAIYVKNHFDHE 423

  Fly   299 EEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILP--RNSSAQSMVRRIE 361
            .:..::::.:.:.:.| ..||.:.:..|:.|:.....|:..|:.::. .|  .|..|     .:.
 Worm   424 AKQQVEEMISLIMESF-VDLLLSEDWLTKETKQTAKQKVNEMKRKIG-YPDYLNDPA-----AVN 481

  Fly   362 RHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYAS 426
            ..|:...:....|:         ......|.|     :.|.:: .||:::......|.| ....:
 Worm   482 NEYKTFKVYPGHYY---------QTKFSFYEQ-----YQRDVL-ERITEAVDRERWVAG-AALVN 530

  Fly   427 AFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVD 491
            |||....|.:|.|..:|:|.||:...||.:.:..:|.::|||::||||..|..:.:.|    .:.
 Worm   531 AFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLG----NIR 591

  Fly   492 RELDRN--PRFQQELGCLRRRF-------------GRK-RYEKFADASGLELAYSAYFDTAQTDH 540
            :..|..  .:|:.:..|:.:::             |:. :.|..||..||:.||.||    :...
 Worm   592 QWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAY----KKYE 652

  Fly   541 KRNRSAEEL----VTQKQQFFHNFAQFFC---SDKEL---LQAHDHGSDRKRVNDAVAHFEPFRE 595
            ||:.....|    :|..|.||.|:||.:|   :|||.   |:..:|.....||...:::...|.:
 Worm   653 KRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAK 717

  Fly   596 AFSCGPSPR---RRQCRLY 611
            |::|.|..:   |.:||::
 Worm   718 AYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	146/710 (21%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	148/721 (21%)