Protein Alignment frma and nep-18

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 745
• Identity: 156/745 - (20%)
• Similarity: 275/745 - (36%)
• Gaps: 221/745 - (29%)

  Fly    12 VGLLVVQVKSHPQA--DPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLLDNEREDD 74
            ||:|.: :|::..|  |||::|::..||.:|.....|:...::......|| ..|......:.:.
 Worm    33 VGVLAM-IKNYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLLYQ-VFAIARKTNKFNS 95

  Fly    75 EPHFLQQLRNFYTAC--RKPLSQD--QVLR--ILEH--LIVMENIQNEE-----------LSVGL 120
            :|:  :|||.|..:|  ||.:.:|  |.||  |.|.  ..:::...|||           ||:..
 Worm    96 KPN--EQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMIDPNWNEEKFDLSDMLAKYLSINR 158

  Fly   121 TAAFRLQV----LIDLNDSNTYDIWKQLMSHRKHWDPN---------------------TTNREP 160
            .....|.|    .|:.|.|    :.:..:|...||..|                     ..|||
 Worm   159 NRMGFLSVEPYAAIEGNKS----VNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRE- 218

  Fly   161 LTREMFDKLWASLPKIPFPFK-----------------------------EYYWREL-------- 188
            |...::||.:|.|.::...|.                             |..|.::
 Worm   219 LNETIYDKEFAELVQLEANFSTLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHG 283

  Fly   189 --SELEEKIMS----YGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFI 247
              .|.|||::.    :|:.:..|.....:.||            .|....|.:|::|.::....:
 Worm   284 TSEEDEEKLLERVTVHGAGEYFFGENRELARI------------ATETPKSALANYLVVRQLIDV 336

  Fly   248 LTYIYMRLKLVAEGVSTESWHIDRDQ---------------CAEQSRQILSHPAA-WLVEKNHPR 296
            ..|.|                 |:||               ||.|.......|:. ..:|.:..:
 Worm   337 ALYFY-----------------DKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFK 384

  Fly   297 LKEEPVLQDIFAELKQRFGQKLLANRNNFTR-STQHFLLGKLKRMRLRLSILPRNSSAQSMVRRI 360
            ::...|::::|.::|..:.|  :...|.:.. ..:.||:.||..:..:.. |.:.:..:.:   :
 Worm   385 IENLKVIEEMFVKIKAEYEQ--IFTENEYLELEIREFLIRKLNAIDGKFG-LDQYTEGKPL---L 443

  Fly   361 ERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYA 425
            |:.|..::.            |:.....:.|.::|. .:..||:...:..:.|.|..::.:||:|
 Worm   444 EKMYETLNF------------LDTDSPWQVYMKMWR-HWSEQLVEHIVHDTPLDPVNLKMFGTHA 495

  Fly   426 SAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAV 490
            :  |....|...:.|..|..|:.....|:...|..||:::|||:.|.||.              .
 Worm   496 A--YQPYPNHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDH--------------F 544

  Fly   491 DRELDRNPRFQQ-------------EL--GCLRRRFG--------------RKRYEKFADASGLE 526
            .|:||.:.|.||             ||  .|||.::.              ..|||...|..|:.
 Worm   545 HRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIR 609

  Fly   527 LAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCS-------DKELLQAHDHGSDRKRVN 584
            .|:..:....:.|..|....|  ::::|.||:|:|...|.       .:.:| |..|.::|.|||
 Worm   610 TAFRVFEKVKKEDRFRLPGLE--MSEEQLFFYNYAFRQCDVYNPNKLPRNML-ARQHPTNRYRVN 671

  Fly   585 DAVAHFEPFREAFSC---GPSPRRRQCRLY 611
            ..:.:...|.|||:|   .|.....:|:||
 Worm   672 GVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	148/720 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	148/726 (20%)