Protein Alignment frma and nep-8

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 687
• Identity: 121/687 - (17%)
• Similarity: 231/687 - (33%)
• Gaps: 199/687 - (28%)

  Fly    23 PQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFL-QQLRNFY 86
            |..|||.:|::.:||.:.....::|                       |...:.|.| :|:|.|.
 Worm    74 PSVDPCVDFFQHSCGRFHEQSVSES-----------------------RLQKKKHILRKQIREFL 115

  Fly    87 TACRKPLSQDQVLR--ILEHLIVMENIQNEELSVGLTAAFRLQVLIDLNDSNTYDIWKQLMSHRK 149
            ...:...|:.:.|.  :.:.....:...|:...:...|...:     .||......|..|   .|
 Worm   116 HKIQNSTSKSENLMKLVFDKCEASKKTSNDNYKISRDAIHDV-----FNDIKKIGAWPLL---DK 172

  Fly   150 HWDPN---------------TTNR-------EPLTREMFDKLWASL------------------- 173
            :||.:               .||.       ..||...|.::..:|
 Worm   173 NWDGSKFDLNEMLSNLVKLGATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMISMISEILEA 237

  Fly   174 -------PKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYEN 231
                   .:|...|:||     |.|:.|:..|.|      ||.|...:|..       .:|.:.:
 Worm   238 NGVQPDSEEISKEFEEY-----SSLQMKLAKYQS------SGKLSISLPGV-------RSINFSS 284

  Fly   232 L-SQM------------------AHWLDIKANEFILTYIYMRLKLVAEGVSTE------------ 265
            | ::|                  .|.|..|:||      ...|..:.|..|.:
 Worm   285 LITEMIHPSRVSKIFGKIRVVTSEHPLFFKSNE------TESLDTIIESTSNKTLANFLIFNYIQ 343

  Fly   266 -SWHI----DRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIFAELKQRFGQKLLANRNNF 325
             |::|    .|..|.:..|:.....:..:..:|.........::.:..|||:. ..:::.:..|.
 Worm   344 SSYNIMKGARRGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKN-TLEMIQDTENL 407

  Fly   326 TRSTQHFLLGKLKRMRLRLSILPRNSSAQSMVRRIERHYRDVHMNASDYFGNLHIGLNHSRSHKK 390
            ....:..:|.|::.:::.:. .|.:.....   .:::.:.:..::::|.:..:...||..||.:
 Worm   408 APPVKESMLKKVEAIKVTIG-YPDHFDPPG---TLDKEFENFDLDSTDSYYRIFQKLNRLRSEQ- 467

  Fly   391 YAQLWAIVFGRQLIP-SRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPS 454
              |:..|.....:.| ..:.|              .:|.|...:|.|.|....|:.||:....|.
 Worm   468 --QMEFIAGETPISPIKEVLK--------------VNANYKRSKNALTVFAPFLDDPFFDITYPD 516

  Fly   455 ILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPRFQQELGCLRRR--------F 511
            .:.....||::.||:.|..|:.|:.:..:|.....:  .|:....:.::..||..:        :
 Worm   517 YVNLFFSGFLIAHEIGHSVDANGLGYDENGKPMDGI--RLEHVTEYGKQGQCLVDQYDNYDDPVY 579

  Fly   512 GRKR------YEKFADASGLELAYSAYFDTAQTDHKRNRSAEEL--VTQKQQFFHNFAQFFCSDK 568
            |:|.      .|..||..|.|:.:.||   .:.|..:..|...|  :...|.:|...:..||.::
 Worm   580 GKKMNGTHSINEIIADWVGHEVTWRAY---KKMDTSKMLSLIGLKDINMDQLYFRVQSLLFCRER 641

  Fly   569 ELLQAHD-----HGSDRKRVNDAVAHFEPFREAFSCG 600
            :.:...:     :.:|..|||.|.|..        ||
 Worm   642 DTISLEETLKDVYPTDNFRVNGAYARV--------CG 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	120/685 (18%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	116/669 (17%)