Protein Alignment frma and nep-22

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 703
• Identity: 130/703 - (18%)
• Similarity: 226/703 - (32%)
• Gaps: 214/703 - (30%)

  Fly    12 VGLLVVQVKSHPQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLLDNEREDDEP 76
            ||.|...:.|....|..:|  .:..|....|.|.|.|..         .:.:|::  |:|..|..
 Worm   204 VGTLTYTIASSDYKDHTKN--ALYTGPPGLSLARDFYVK---------PQYIAEV--NQRVSDVN 255

  Fly    77 HFLQQLRNFYTACRKPLSQDQVLRILEHLIVMENIQNEELSVGLTAAFRLQVLIDLNDS-NTYDI 140
            ..|....|   |.:|.:..|.:|...:.::      |.|:.:.: |::...:|.:.... |.|:|
 Worm   256 DLLTAFAN---AAKKNVGADALLAAAQEVV------NFEVQIAM-ASWPDDLLRNYQQQYNPYNI 310

  Fly   141 -----------WKQLMSHRKH----------------------W-----DPNTTNREPLTREMFD 167
                       ||..:....|                      |     |..|:|...:...|..
 Worm   311 ASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIA 375

  Fly   168 KLWA--------SLPKIPFPFKEYYW-----RELSELEEKIMSYGSED-DGFDSG--DLVTRIPP 216
            :|.|        :..|:.......::     |.:.::.::  .|...| ||...|  ||:|.
 Worm   376 QLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKR--EYRMADLDGISEGCMDLLTA--- 435

  Fly   217 FWMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQI 281
              .||:..|                        |:|::.|.....|..:        ..:|:..|
 Worm   436 --YMPYGTG------------------------YVYVKSKSERNKVQAD--------VKDQTTLI 466

  Fly   282 LSH------PAAWL--VEKNHPRLKEEPVLQDIFAELKQRFG--QKLLANRNNFTRSTQHFLLGK 336
            :::      ...|:  ..||....|.:        .|.:.||  :.:..:.|:||
 Worm   467 INNFQGMIDSLNWMDTFSKNRAHNKSD--------SLVKNFGWPEAMFGDFNDFT---------- 513

  Fly   337 LKRMRLRLSILPRNSSAQSMVRRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGR 401
                    ::...|....|::....:...|::    ..|..|..|:......:        :.|.
 Worm   514 --------TVDAYNQDYASIIDLYTKDKNDIY----GIFAVLKKGMEVREFFR--------IMGE 558

  Fly   402 QLIPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILG 466
            ....:...:|   |..|       :|:|..::|.:..|.:...||:|....|....::..|...|
 Worm   559 PADRTNFLQS---PAMV-------NAWYQPERNSITFPYAAWNPPYYNLNYPQAYNFAGQGGTGG 613

  Fly   467 HELSHGFDSEGMTFSSHG--------------VGSSAVDRELDRNPRFQQELGCLRRRFGR---- 513
            |||:||:|.||:.|..:|              ..||:...::.:....|....|...:.|.
 Worm   614 HELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTGNIHCA 678

  Fly   514 ----KRYEKFADASGLELAYSAYFDTAQTDHKRNRSAE----ELVTQKQQFFHNFAQFFC---SD 567
                .:.|..||..|.:.||.:|.....|..|......    |..|..|.|:..:...:|   ||
 Worm   679 NGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYTPNQIFWITYGYSWCMKQSD 743

  Fly   568 KEL---LQAHDHGSDRKRVNDAVAHFEPFREAFSC------GPSPRRRQCRLY 611
            ..|   |..:.|...:.|.|..:.....|.:.|.|      .|.|..| |:::
 Worm   744 ANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGR-CKVW 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	122/678 (18%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	129/699 (18%)