Protein Alignment frma and nep-5

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 716
• Identity: 133/716 - (18%)
• Similarity: 254/716 - (35%)
• Gaps: 247/716 - (34%)

  Fly     3 FKLRLLELIVGLLVVQVKSHPQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLL 67
            :...||||:          ....:||:||:...|..::.  ....:|..|..:  |.|||    .
 Worm   116 YSAELLELM----------DSSVNPCENFHHHVCNGFNP--RKKDFERLMKLI--NIQEK----P 162

  Fly    68 DNER---------------EDDEPHFLQQ-------------LRNFYTACRKPLSQDQ------- 97
            |:.:               :.:|.|.:.:             |.|.:|....|:|...
 Worm   163 DHRKAVNVVRRMLSKCAMGKTEEIHQVGRLSSIILPGLPFPLLNNSWTKPSDPISTSNSSTTYSY 227

  Fly    98 --VLRILEHLIV----------MENIQNEELSVGLTAAFRLQVLIDLNDSNTYDIWKQLMSHRKH 150
              :.:||.|:|:          ::...:.|.|:.:...|. .||.:....|.|||.|      ::
 Worm   228 PFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFVVKPFS-PVLTNFKFRNMYDILK------RN 285

  Fly   151 WDPNTTN--------REPLTREMFD--KLWASLPKIPFPFKEYYWRELSELEEK--IMSYGSEDD 203
            ...::||        |:   |::.|  ||...|.||.|. .:.....|:|::.:  |:.:
 Worm   286 APESSTNGMIDLEFDRQ---RQLNDVIKLQTKLEKIEFK-ADPEVVNLTEIQRQMPIIDW----- 341

  Fly   204 GFDSGDLVTRIPPFWMMPWPNGNITYENLSQ------MAHWLDIKA------NEFILTYIYMR-- 254
                    .|:...|:   |||   |.:|.:      .:::.:|.|      :|.|..::::|
 Worm   342 --------KRLIDSWI---PNG---YAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRFS 392

  Fly   255 LKLVAEGVSTESWHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEP--------VLQDIFAELK 311
            .|.:...|:::.    .|.|..|....:  |...::..:     |||        :|..|..:||
 Worm   393 FKFLRTEVASDL----EDTCLHQLSTTI--PGKIVLYGS-----EEPEALNLLNGMLHTIKDQLK 446

  Fly   312 QRFGQ-KLLANRN--------NFTRSTQHF--------LLGKLKRMRLRLSILPRNSSAQSMVRR 359
            :.... |.:.:|.        |.|::...|        |:||         |.|.::...::...
 Worm   447 RSLATLKWMDSRGIEEAQKKFNKTKTVFGFTGEDLIDELVGK---------ITPESNYISTLQNV 502

  Fly   360 IERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTY 424
            :....|::..:.::  .|:.:.||
 Worm   503 LLWQTRNMFKSVAE--NNVTVFLN----------------------------------------- 524

  Fly   425 ASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSA 489
            :..||.|::|.:.:..:||..||.:...|:...::.:...:..::.|.||..|..:.|.|...:.
 Worm   525 SEVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNW 589

  Fly   490 VDRELDRNPRFQQELGC----LRRRFGRKRYEKFADASGLELAYSAYFDTAQ---TDHKRNRSAE 547
            .:.|.:|  .||..:.|    ::..||          ..:.:.::||..|.:   |.....:|::
 Worm   590 WNTETER--YFQIIVQCFDGMMQNVFG----------VSVSIGWNAYDSTKEPYATLPGIQQSSD 642

  Fly   548 ELVTQKQQFFHNFAQFFCSDKELLQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSPRRR---QCR 609
            |.:     ||::..:..|:           ||...||:|:|....|..||.|....:..   :|:
 Worm   643 EAL-----FFYSMVKTMCT-----------SDPDNVNEALASVPQFNSAFKCNNGTKMNPPTKCK 691

  Fly   610 L 610
            |
 Worm   692 L 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	127/680 (19%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	127/691 (18%)