Protein Alignment frma and nep-12

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 747
• Identity: 158/747 - (21%)
• Similarity: 259/747 - (34%)
• Gaps: 245/747 - (32%)

  Fly    25 ADPCQNFYKVACGNWSASHATDSYE---SFMDRLDYNYQEKLADLLDNEREDDEPHFLQQLRNFY 86
            |:||::||:.|||.::.......:|   :.:..:.......|.|:|:....::....::..:.::
 Worm   171 ANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSRENTTRSMKLAQIYF 235

  Fly    87 TACRKPLSQDQVLRILEHLIVMENI----------------QNEELS-----VGLTAAFRLQVLI 130
            .:|....|||. |.:...:.::.|:                |.|.|:     .|:...||:.|..
 Worm   236 DSCMDEFSQDD-LGVQPLMSMISNLGGWPLLTNARFDSIDFQWEVLAGHLALYGVDGIFRVFVHS 299

  Fly   131 DLNDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYWRE-------L 188
            ..:||                |.|.             |..|.||: |..|:.::||       |
 Worm   300 SFDDS----------------DKNV-------------LMFSPPKL-FLEKKKFYREVPSSNVYL 334

  Fly   189 SELEEKIMSYGS------EDD----GFDSGDLV---------TRIPPFWMMPWPNGNITY----- 229
            ....:.|:|..|      ||:    .:...|::         |||.........|..||:
 Worm   335 QYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRNHSSINNMITFGEFKR 399

  Fly   230 ----------------ENLSQMAHWLDIK---ANEFILTYIYMRLK------------LVAE--- 260
                            .||.:|...|.|.   .|.|...|..::.|            ||:.
 Worm   400 KYDKINWDAFFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDM 464

  Fly   261 ------------------GVSTES--WHIDRDQCAEQSRQILSHPAAWLVEKNHPRLKEEPVLQD 305
                              |||::.  |.:    |..:.|:.|:.|.:....:.....|::.|.:|
 Worm   465 YLPAKYRKPMLDFRQKMYGVSSDDPLWEV----CVGEVRENLAMPLSTEYAQKFFTKKDKLVAED 525

  Fly   306 IFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRL----SILPRNSSAQSMVRRIERHYRD 366
            :..:||:...|.|| |.:....||:...|.||..|..::    |:|  |.:|      :...|..
 Worm   526 MIRDLKKAMEQTLL-NADWIDESTREAALMKLDAMGHKIGFPDSLL--NETA------VLLPYAG 581

  Fly   367 VHMNASDYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYAS----- 426
            |.:.|:.||.|                  ||...:......:||....|:.:    .:||
 Worm   582 VRLTANQYFDN------------------AISLKKAAYRDALSKLHRTPSLI----DWASPIIAV 624

  Fly   427 -AFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAV 490
             ||:....|.:|.|..:|:.|.:....|:...|.|:|..:|||::||:|..|..:...|
 Worm   625 DAFHYFTGNEIIFPAGILQFPMFVPDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKG------ 683

  Fly   491 DRELDRNPR----------FQQELGCLRRRFGRKRY--------------EKFADASGLELAYSA 531
                  |.|          ||::..|...::|.|..              |..||..||.:|:.|
 Worm   684 ------NLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTIGENIADNGGLRVAFQA 742

  Fly   532 YFDTAQTDHKRNRSAEEL-----VTQKQQFFHNFAQFFCSDKELLQ--AHDHGSDRK-------R 582
            |    |....|.:....|     .:..|.||..:|..:|   |.|:  |.||..|..       |
 Worm   743 Y----QLRSDREKETRRLPGLTDFSPNQLFFLAYANTWC---EALKPSAIDHIMDTDVHSLGMFR 800

  Fly   583 VNDAVAHFEPFREAFSC---GPSPRRRQCRLY 611
            ||..:.:...|.:.|.|   .|.....:||::
 Worm   801 VNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	155/735 (21%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	156/743 (21%)