DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frma and Ecel1

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	687	Identity:	158/687 - (22%)
Similarity:	250/687 - (36%)	Gaps:	161/687 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPCQNFYKVACGNWSASHATDSYESFMDRLDY--------NYQEKLADLLDNEREDDEPHFLQQL 82
            ||||:||..|||.|...||...     |:|.|        ..:|:|..||............:::
Mouse   122 DPCQDFYSFACGGWLRRHAIPD-----DKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKV 181

  Fly    83 RNFYTACRKPLSQDQVLRI-----LEHLIVMENIQNEELS-----------------------VG 119
            |.|:.:|   |...::.|:     ||   |:|:....:|.                       ..
Mouse   182 RAFFRSC---LDMREIERLGPRPMLE---VIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYS 240

  Fly   120 LTAAFRLQVLIDLNDSNTYDIWKQLMSHRKHWDPNTTNREPL---TREMFDKLWAS--------L 173
            ..|.|.|.|.:|..:|:.|.|       |...|..|.....|   ..|..:|:.|:        |
Mouse   241 AAALFSLTVSLDDRNSSRYVI-------RIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLL 298

  Fly   174 PKIPFPFKEYYWRELSELEEKI--MSYGSEDD-------GFDSGDL--VTRIPPFWMMPWPNGNI 227
            ..:.....|...:|:.:||:::  :|....||       .::...|  :.:|.|.....|....|
Mouse   299 RLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQI 363

  Fly   228 TYENLS--------------QMAHWLDIKANEFILTYIYMRLKLV-AEGVST---ESWH------ 268
            ..|:.|              |::..:.......:..|:..|:.:| :|.:|:   |:.|
Mouse   364 FQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEM 428

  Fly   269 --IDRDQ-----CAEQSRQILSHPAAWLVEKNHPRLKEEPVLQDIFAELKQRFGQKLLANRNNFT 326
              .|:.|     |..|:.:........|....|.....:..:|.:..::|...||: |...:...
Mouse   429 EGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQR-LEELDWMD 492

  Fly   327 RSTQHFLLGKLKRMRLRLS-----ILPRNSSAQSMVRRIERHYR-DVHMNASDYFGNLHIGLNHS 385
            ..|:.....||:.|.:.:.     :.|         ..:::.|. :||  ...||.|:   ||..
Mouse   493 AQTKAAARAKLQYMMVMVGYPDFLLKP---------EAVDKEYEFEVH--EKTYFKNI---LNSI 543

  Fly   386 RSHKKYAQLWAIVFGRQLIPSRISKSD-LYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYT 449
            |        ::|....:.|...:.||. |.|.|.      .:|:|:..:|.::.|..:|:|..|.
Mouse   544 R--------FSIQLSVKKIRQEVDKSSWLLPPQA------LNAYYLPNKNQMVFPAGILQPTLYD 594

  Fly   450 HGQPSILTYSALGFILGHELSHGFDSEGMTFSSHG--------VGSSAVDRELDRNPRFQQELGC 506
            ...|..|.|..:|.|:||||:||:|..|..:...|        ...|...|:.:...|.......
Mouse   595 PDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTV 659

  Fly   507 LRRRFGRKRY--EKFADASGLELAYSAYFDTAQTDHKRNRSAEEL-VTQKQQFFHNFAQFFC--- 565
            ..:|...|..  |..||..||:|||.||....: :|........| .|..|.||..|||.:|
Mouse   660 YNQRVNGKHTLGENIADMGGLKLAYYAYQKWVR-EHGPEHPLHRLKYTHNQLFFIAFAQNWCIKR 723

  Fly   566 -SDKELLQ--AHDHGSDRKRVNDAVAHFEPFREAFSC 599
             |....||  ...|..:..||..:|:.||.|..||.|
Mouse   724 RSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHC 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	158/687 (23%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	158/687 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010