Protein Alignment frma and Nep2

DIOPT Version :10

• Sequence 1: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: XP_061497288.1
• Gene: Nep2 / 1281326
• VectorBaseID: AGAMI1_002834
• Length: 792
• Species: Anopheles gambiae
• Alignment Length: 714
• Identity: 137/714 - (19%)
• Similarity: 263/714 - (36%)
• Gaps: 177/714 - (24%)

  Fly    24 QADPCQNFYKVACGNW-------SASHATDSYESFMDRLDYNYQEKLADLLDNEREDDEPHFLQQ 81
            :.:||.:||..|||.:       ....:.:::....|||    |::|..|:..|..|.|....:.
Mosquito   130 EVEPCDDFYNYACGKFVKETVIPDEKVSVNTFSVIGDRL----QQQLRSLVSEEISDSEATPFKL 190

  Fly    82 LRNFYTAC--RKPLSQDQVLRILE-HLIV----------------------MENIQNE------- 114
            .:|.|..|  :..:.:..:..:|: |.::                      :::.:|.
Mosquito   191 AKNLYKLCMNKTRIEEKGIKPLLDIHEVLGGWPVLKGDSWDLDSSWSWVKSVKDFRNNGYSTDYF 255

  Fly   115 -ELSVGLTAAFRLQVLIDLNDS------------------NTYDIWKQLMSHRKHWDPNTTNREP 160
             :.|:|.......:.:||.:.:                  :.|..:...|:.....|.....||.
Mosquito   256 FDFSIGSDLKNSTRRIIDTDQASLGISREYLVKGMENPIVSAYYNYMVDMAVLLGADEERAKREL 320

  Fly   161 LTREMFDKLWA--SLPK----------IPFPFKE----YYWRELSELEEKIMSYGSEDDGFDSGD 209
            |....|:...|  |||.          .|...||    |.:.:..|....|:    :|.|...|:
Mosquito   321 LDSLNFEMALANISLPNEKRRNATALYNPMTVKEFQQRYPYTDWLEYFNAIL----KDTGIVIGE 381

  Fly   210 ---LVTRIPPFWMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDR 271
               ::..:|.|              :.|:...|.......:..|:..|:...:....||..
Mosquito   382 EEVIIVSVPTF--------------MEQLGPLLQNTPKRVMANYVMWRISGFSSFFLTEKL---- 428

  Fly   272 DQCAEQSRQILSHPAAWLVEKNHPRLKE--------EPV------LQDIFAELKQRFGQKLLANR 322
                 :.||:....|....::..||.||        .|:      ::..|.|..:|....::
Mosquito   429 -----RKRQLQYSTALSGKQEQEPRWKECVDITSGSLPISVGALYIRKYFREDSKRAALDMV--- 485

  Fly   323 NNFTRSTQHFLLGKLKRMR--LRLSILPRNSSAQSMV---------RRIERHYRDVHMNASDYFG 376
             |..:|....:|.|:..|.  .|:|.|.:.|:..:.:         .:|..:|:|:.......:.
Mosquito   486 -NDIKSVFVDILKKVDWMDEVTRVSALEKVSTMATHIGYPDELMDDAKIAEYYKDLEFQPDSTYL 549

  Fly   377 NLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLS 441
            |..:.:|...:.|.:.:|...|          :|:| :.|..|  ....:|||...:|.:..|..
Mosquito   550 NTILYMNKFGTTKAFKKLRIAV----------NKTD-WITHSR--PAIVNAFYSSIENSIQFPAG 601

  Fly   442 LLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVD-RELDRNPRFQQELG 505
            :|:..|:::.:|..:.|.|:||::|||::||||.:|..|..:|   :.|| .:.|....:.::..
Mosquito   602 ILQGQFFSYDRPKYMNYGAIGFVIGHEITHGFDDQGRQFDKNG---NLVDWWQSDTKTAYLEKAR 663

  Fly   506 CLRRRFG--------------RKRYEKFADASGLELAYSAYFDTAQTDHKRNRSAEELVTQKQQF 556
            |:..::|              ..:.|..||..|::.||.||....:.:....|.....::.:|.|
Mosquito   664 CIIEQYGNYTEPNVKLNLNGINTQGENIADNGGIKEAYYAYRRWTEKNGPEQRLPGLNLSPEQMF 728

  Fly   557 FHNFAQFFCS------DKELLQAHDHGSDRKRVNDAVAHFEPFREAFSC---GPSPRRRQCRLY 611
            :.:.||.:||      .|..:....|...:.||...:::...|.:.|:|   .|.....:|.::
Mosquito   729 WLSAAQTWCSVYRPETMKMRITTGVHSPGQFRVLGPMSNMHEFAKDFNCPVGSPMNPEHKCEVW 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:472708	135/701 (19%)
Nep2	XP_061497288.1	None