DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frma and kel

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	611	Identity:	120/611 - (19%)
Similarity:	199/611 - (32%)	Gaps:	211/611 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DEPHF----------------LQQLRNFYTACRKPLSQDQVLRILEHLIVM-----ENIQNEELS 117
            |||||                .:.||.||:||.            ::|:::     ...|:..|.
Zfish   270 DEPHFQFPIEWNSKTQKAKANTRYLRPFYSACG------------QYLVLLGVPSDRTTQHCGLF 322

  Fly   118 VGLT-----AAFRLQVLIDLNDSNTYDIWKQLMSHRKHWDPNTTNREPLT-----------REMF 166
            |.|:     |.|.|          .|.:.::|:..|      ||.:|..|           :..|
Zfish   323 VSLSTTLAVATFPL----------PYRLSQKLLYRR------TTIQELQTLAPAVDWLACLQATF 371

  Fly   167 DKLWAS---------LPKIPFPFKEYYWRELSELEEKIMSYGSEDDGFDSGDLVTRIPP-----F 217
            ..|..|         ||.|....|..:   |.:::.::|..|..:.......|.|.||.     |
Zfish   372 QPLLISKSDIVLVHNLPYIIHMSKTIH---LWQVQHELMGTGPLNTYMIFSLLQTLIPALDSRFF 433

  Fly   218 WMMPWPNGNITYENLSQMAHWLDIKANEFILTYIYMRLKLVAEGVSTESWHIDRDQCAEQSRQ-- 280
            .:|  .|.:|...:..:|.||                            |     :|.:|:.:
Zfish   434 QIM--RNYSIATGDTQEMPHW----------------------------W-----RCVQQTERGF 463

  Fly   281 --ILSHPAAWLVEKNHPRLKEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLR 343
              :|||    .:.:.|.:.:.|.::||:::.||     |.|.:.:........|:|.|:..:..|
Zfish   464 DTLLSH----AIREKHAQKEAEELIQDVYSSLK-----KKLTDLSWRDEKESDFILNKINSLNPR 519

  Fly   344 LSILPRNSSAQSMVRRIERHYRDVHMNASDYFGN-LHIGLNHSRSHKKYAQLWAIVFGRQLIPSR 407
            :|....|.|    ...:...|..|.:|..|:|.| |.|.|...:|..:...|.....|..:.|
Zfish   520 ISTNTNNLS----YTELNHLYEKVILNEEDFFSNYLQILLLEQKSRARLLSLGTQTEGLSMTP-- 578

  Fly   408 ISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSH- 471
                                  .:..|.:|||:.:...||:....|..|.|..||.::..:|.|
Zfish   579 ----------------------FISGNDIIVPVGMFVSPFFHSSYPRALNYGTLGSLMAKDLLHL 621

  Fly   472 ----------GFDSEGMTFSSHGVGSSAVDRELDRNPRFQQELGCLRRRFGRKRYEKFADASGLE 526
                      ..::|.:...||.:       .:.:.|.:    |........|:.|.:...|.|:
Zfish   622 LLPDIYTKAKNPETESLCVWSHYL-------SVTKGPGW----GDAFYLPSSKQQEVWVQYSALQ 675

  Fly   527 LAYSAYFDTAQTDHKRNRSAEEL--VTQKQQFFHNFAQFFCSDKELLQAHDHGSDRKRVNDAVAH 589
            :|..||    :...||..:...|  .:....|..:|.:..|.                 .||...
Zfish   676 VALDAY----KMSFKRYLADSSLPGFSYVHLFLSSFTKVTCD-----------------TDAYRE 719

  Fly   590 FEPFREAF-------SCGPSPRRRQC 608
            |.|...:|       :.|..|:...|
Zfish   720 FMPLEPSFLVTVLCSNSGLCPKPLTC 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	117/602 (19%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	93/452 (21%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	33/169 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010