DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frma and LOC100332538

DIOPT Version :9

Sequence 1:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	749	Identity:	169/749 - (22%)
Similarity:	254/749 - (33%)	Gaps:	252/749 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VQVKSHPQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNY--------QEKLADLLD----- 68
            ||....|...||.:||..|||.|...|....     |:|.|..        |:||..||.
Zfish   138 VQGNIDPSVQPCHDFYSFACGGWLRRHGIPE-----DKLSYGIITAIGEQNQDKLQRLLQAPVQR 197

  Fly    69 NEREDDEPHFLQQLRNFYTAC---------------------------------------RKPLS 94
            .|.|..|    ::::.||.:|                                       ..|:.
Zfish   198 RELESAE----RKVKEFYRSCINIKEIDRLGAGPMTEVIDSCGGWDLSGAPPGGAGWDSGSAPIR 258

  Fly    95 QDQVLRILEHLIVMENIQNEELSVGLTAAF------RLQVLID-----LNDSNTY-----DIWKQ 143
            .|    ..|.|...:.:.:..:...||.:.      |..:.||     |.:...|     |..|.
Zfish   259 PD----FNEMLYKTQGVYSTSVFFSLTVSVDDKNSSRNAIRIDQEGLTLPERTLYLGQDEDSVKI 319

  Fly   144 LMSHRKHWDPNTTNREPLTREMFDKLWASLPKIPFPFKEYYWRELSELEEK-----IMSYGSEDD 203
            |.|:               :.:.::|.:.|.......|.   ||:.:||.|     :..|  ||.
Zfish   320 LASY---------------KALMERLLSMLGAHNATLKS---REILDLETKLANITVSEY--EDQ 364

  Fly   204 GFDSGDLVTRIPPFWMMPWPNGNITYENLSQMA---HW---LD--------------IKANEFIL 248
            ..|...:..|             ||.:.|.:||   ||   ||              :.|.:::.
Zfish   365 RKDISSMYNR-------------ITLKQLQKMAPSFHWKRLLDRIFNDNFSEEEEIVVLATDYMQ 416

  Fly   249 T-------------YIYMRLKLVA---EGVSTE--------SWHIDRDQ--------CAEQSRQI 281
            |             :.||..::||   |.:||.        |..||..:        |..|:.:.
Zfish   417 TVSDIIKTTSKRVLHNYMLWRMVAALSEHLSTAFRSTIHEFSREIDGTEQQLDLERLCLTQANKH 481

  Fly   282 LSHPAAWLVEKNH----PRLKEEPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRL 342
            .......|..:.|    .|.|.:.:::||...|..|     |...:.....|:....|||:.|.:
Zfish   482 FGMALGALFVQQHFSSSSRAKVQELVEDIKHSLDVR-----LQELDWMDEETKDAARGKLQHMMV 541

  Fly   343 RLS-----ILPRNSSAQSMVRRIERHYR-DVHMNASDYFGNL------HIGLNHSRSHKKYAQ-L 394
            ...     :.|         ..|:..|. ||  |...||.|:      :|.|:..:.||:..: .
Zfish   542 MTGYPDFLLKP---------ELIDEEYAFDV--NEKTYFKNILNSIKYNIKLSIKKIHKEVDKTT 595

  Fly   395 WAIVFGRQLIPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEPPFYTHGQPSILTYS 459
            |                 |.|.|.      .:|:|:..:|.::.|..:|:|..|....|..|.|.
Zfish   596 W-----------------LLPPQA------LNAYYLPNKNQMVFPAGILQPTLYDPEFPQSLNYG 637

  Fly   460 ALGFILGHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPRFQQELGCL-----------RRRFGR 513
            .:|.|:||||:||:|..|..:..:|........|..|  :||::..|:           :|..||
Zfish   638 GIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTEESYR--KFQKKTECIVKLYDNFTVYNQRVNGR 700

  Fly   514 KRY-EKFADASGLELAYSAYFDTAQTDHKRNRSAEELV-TQKQQFFHNFAQFFCSDKE------L 570
            ... |..||..||:|:|.||....: :|...|....|. |.:|.||..|||.:|..:.      .
Zfish   701 LTLGENIADLGGLKLSYHAYQKWVR-EHGPERPLPGLKHTHEQLFFIAFAQNWCMKRRSQSIYLQ 764

  Fly   571 LQAHDHGSDRKRVNDAVAHFEPFREAFSCGPSPR 604
            |....|..:..||..:|:.||.|...|.|   ||
Zfish   765 LLTDKHAPEHYRVIGSVSQFEEFGRVFHC---PR 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frma	NP_572226.2	GluZincin	25..601	CDD:301352	164/736 (22%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	166/741 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010