DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmprss9 and flz

DIOPT Version :9

Sequence 1:	NP_001382445.1	Gene:	Tmprss9 / 314636	RGDID:	1309581	Length:	1095	Species:	Rattus norvegicus
Sequence 2:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	180/733 - (24%)
Similarity:	266/733 - (36%)	Gaps:	188/733 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat   470 VTSSADTPVVPT----EAPAPITPSTP----WPTSPESRVPNTTAKPTVAPTPAPLHPSTAAKPQ 526
            :.|:|:..|..|    :.|...|.|||    .|||..|..........:..||.|..|:....|
  Fly  1029 IQSTAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLITP- 1092

  Rat   527 ECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGSRHFCGATVVGDRWLLSAAHCFNHTKLEQVQ 591
                     |||.|         .:...:||.:.|.....:|                      .
  Fly  1093 ---------KPTAI---------NLVTYSSLSDDSNKLASST----------------------S 1117

  Rat   592 AHL-GTVSLLGV-----------GGSPVKLGLRSVALHPRY----------------NPGILDFD 628
            ::: |...:.||           |.|||.:..........|                .|....|.
  Fly  1118 SYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYAVPSDDKPAFPGYFGPTPSYPAFS 1182

  Rat   629 VALLELAQPLVFNKYIQP---VCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIE 690
            |...::.|.::...|..|   |..|      ||....:     ||...::.....|..::...:|
  Fly  1183 VPGEKVGQNVMEETYTSPNDFVNFP------PVRNPNL-----NMSAASSAVTSDLDLSTPAFVE 1236

  Rat   691 QKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPG-----VFYLAGI--VSWGIGC 748
            ..:        |.|:|  ...:...|.|.||:........|.||     ..|.||.  .:..:..
  Fly  1237 DVV--------LKDKM--HTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVRV 1291

  Rat   749 AQAKKPGVYARITRLKDWILKAMSSDPSSTAHPHTSSTRLIPSQPPT--TTAAGLIPEASTGRPA 811
            ...:||...|..||.|....|.::...:...:..||:......:|.|  ||.|..: ..:|.|||
  Fly  1292 VTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKV-TTTTRRPA 1355

  Rat   812 TLRATIRVTTRPLNTTLSA-----------------------------------------RSTTT 835
            |.:.|.||::....||:|:                                         :..:|
  Fly  1356 TKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHST 1420

  Rat   836 RRQTPAPGTTVFSHLPDCGLAPPGALTRIVGGSAASLGEWPWQV----SLWLRR-REHRCGAVLV 895
            .|..|.|.....|...:||:.|.....|||||..::.|.:||||    |.||.. .:::||.||:
  Fly  1421 SRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLI 1485

  Rat   896 AERWLLSAAHC--------------FDVYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNI 946
            ..|::::||||              ||:.||            |.|.....:.|.|:..|..|:.
  Fly  1486 TSRYVITAAHCQPGFLASLVAVMGEFDISGD------------LESKRSVTKNVKRVIVHRQYDP 1538

  Rat   947 YTLDYDVALLELAGPVRRSRLVRPICLPGPTRPPEGARCVITGWGSLREGGSMARQLQKAAVRVL 1011
            .|.:.|:|||||..||:....:.|||:|.......|....:||||.|:.||.:...||:..|.::
  Fly  1539 ATFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVLQEVQVPII 1603

  Rat  1012 SEQTCRRFYPV-----QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCG 1071
            ....|:..:..     :|.:..||||:..|..|||.||:||||..:.|.|::.|.|..|.|..|.
  Fly  1604 ENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCA 1668

  Rat  1072 RPHFPGVYTRVAAVLGWI 1089
            .|:.||||.|......|:
  Fly  1669 APYLPGVYMRTTFYKPWL 1686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmprss9	NP_001382445.1	None
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021	20/76 (26%)
		Tryp_SPc	1449..1689	CDD:238113	85/250 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3705
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960