DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and Cysltr1

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001268788.1	Gene:	Cysltr1 / 58861	MGIID:	1926218	Length:	352	Species:	Mus musculus

Alignment Length:	375	Identity:	70/375 - (18%)
Similarity:	138/375 - (36%)	Gaps:	80/375 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EDNNISYWNLTC-DSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSK----KSMATPTNFVLMG 129
            |:...|..|.|| |:..|:...:|......:.::....||.::.||.|    ||   .....::.
Mouse    18 ENLTTSLINNTCHDTIDEFRNQVYSTMYSVISVVGFFGNSFVLYVLIKTYHEKS---AFQVYMIN 79

  Fly   130 MAICDMLTV-IFPAPGLWYM----YTFGNHYKPLHPVSMC--LAYSIFNEIMPAMCHTISVWLTL 187
            :||.|:|.| ..|...::|:    :.||:.        :|  ..|:::..:   .|   |::...
Mouse    80 LAIADLLCVCTLPLRVVYYVHKGKWLFGDF--------LCRLTTYALYVNL---YC---SIFFMT 130

  Fly   188 ALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCH 252
            |::..|.:.:..........|..:.|.....|.:...|...|....::|..   |.|.  |:...
Mouse   131 AMSFFRCVAIVFPVQNINLVTQKKARFVCIGIWIFVILTSSPFLMYKSYQD---EKNN--TKCFE 190

  Fly   253 LETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKE 317
            ...:.....|:.:..|.:.::.|.:.||.::.|..::.|.:|.....:....|||.:.
Mouse   191 PPQNNQAKKYVLILHYVSLFFGFIIPFVTIIVCYTMIILTLLKNTMKKNMPSRRKAIG------- 248

  Fly   318 CKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHI---------------VSSLIIEFLDYGLA 367
                        |:|||.:.||::.:|..:...:|:               :...::..|....:
Mouse   249 ------------MIIVVTAAFLVSFMPYHIQRTIHLHLLHSETRPCDSVLRMQKSVVITLSLAAS 301

  Fly   368 NICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRL--MAKKDSS 415
            |.|.          .|:.:....|..|:...||::..|..:  :.||.:|
Mouse   302 NCCF----------DPLLYFFSGGNFRRRLSTFRKHSLSSMTYVPKKKAS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	57/335 (17%)
		TM helix 1	92..116	CDD:410630	5/23 (22%)
		TM helix 2	124..146	CDD:410630	6/22 (27%)
		TM helix 3	169..191	CDD:410630	3/21 (14%)
		TM helix 4	214..230	CDD:410630	2/15 (13%)
		TM helix 5	270..293	CDD:410630	5/22 (23%)
		TM helix 6	328..353	CDD:410630	7/24 (29%)
		TM helix 7	368..393	CDD:410630	4/24 (17%)
Cysltr1	NP_001268788.1	7tm_4	47..264	CDD:304433	48/257 (19%)
Cysltr1	NP_001268788.1	7tm_1	55..310	CDD:278431	54/305 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000