DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPR and FMRFaR

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	121/531 - (22%)
Similarity:	204/531 - (38%)	Gaps:	146/531 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TDVLYQYRLAPSASPEMEMELADPRQMVRGFHLPTNESQLEIPDYGNES-----LDYPNYQQMVG 64
            ||  |.|....|....:...:|.....||....|.|.||..:....|.:     |.||:|:.:..
  Fly    26 TD--YDYGGPISDDEFLASAMATEGPTVRYDLFPQNNSQPTLQIVLNHTEVQTDLQYPHYEDLGL 88

  Fly    65 GP-------CR------MEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSK 116
            .|       |.      :|:|.|.:|  .|           |..:..:.::.|:.|.:.:::||:
  Fly    89 DPDPNWTRICEDVYNPLLENNRIEFW--VC-----------GVLINIVGVLGILGNIISMIILSR 140

  Fly   117 KSMATPTNFVLMGMAICDMLTVI-----FPAPGLWYMYT--FGNHYKPLHPVSMCLAYSIFNEIM 174
            ..|.:..|::|.|:|.||.:.:|     |..|.: |.||  |..:|..::|.           |.
  Fly   141 PQMRSSINYLLTGLARCDTVLIITSILLFGIPSI-YPYTGHFFGYYNYVYPF-----------IS 193

  Fly   175 PA------MCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFD 233
            ||      :..|.|:::|..:.::||:.|||...||..||..|.:.........:..:.:|||::
  Fly   194 PAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWE 258

  Fly   234 --------------------------RTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSY 272
                                      .||:.:.|.|       |:|     :.:||
  Fly   259 VLTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHW-------CYL-----IVNYI--------- 302

  Fly   273 YLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSV 337
                      :|.:.|..||.|::..:::|...|:.|.|..:       ||....|::|.||:..
  Fly   303 ----------IPFLTLAILNCLIYRQVKRANRERQRLSRSEK-------REIGLATMLLCVVIVF 350

  Fly   338 FLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKE 402
            |:|..:|:.:     .:|......:|:.:..|    :|..:..:..:||.||.    .|.|.||.
  Fly   351 FMLNFLPLVL-----NISEAFYSTIDHKITKI----SNLLITINSSVNFLIYI----IFGEKFKR 402

  Fly   403 IFLGRLMAKKDSSTKYSIVNGARTCTNTNETVLXXLVMLVPRRGSSDHRRSSTSTTTTTT----T 463
            |||.....::.|..:..:::...:.:|..:..|.       .|.|....|..|..:||||    |
  Fly   403 IFLLIFFKRRLSRDQPDLIHYESSISNNGDGTLN-------HRSSGRFSRHGTQRSTTTTYLVAT 460

  Fly   464 KTIGGSMIIGG 474
            ...||....||
  Fly   461 GGPGGGGCGGG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	76/348 (22%)
		TM helix 1	92..116	CDD:410630	4/23 (17%)
		TM helix 2	124..146	CDD:410630	9/26 (35%)
		TM helix 3	169..191	CDD:410630	6/27 (22%)
		TM helix 4	214..230	CDD:410630	0/15 (0%)
		TM helix 5	270..293	CDD:410630	3/22 (14%)
		TM helix 6	328..353	CDD:410630	7/24 (29%)
		TM helix 7	368..393	CDD:410630	6/24 (25%)
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	72/330 (22%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	70/321 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6566
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930