DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPR and K01A6.6

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001255582.1	Gene:	K01A6.6 / 3565516	WormBaseID:	WBGene00010448	Length:	459	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	82/416 - (19%)
Similarity:	152/416 - (36%)	Gaps:	108/416 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDN------------------------NISY 76
            ||.|.:        |:|.|...|...:....|..||.                        |:.:
Worm     2 HLTTID--------GDEDLRIHNISILPSDQCATEDQRAAKCCCGDGFFFDFPRKKCEISANVGF 58

  Fly    77 --------WNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKS-------MATPTNFV 126
                    |:         .|.:||:..|.:|::.|.....::|.:.|:.       ...|...:
Worm    59 MFGRLNNGWS---------HMAVYGFAYPMILLMLIAPLCAVMLGMGKREKREGDRRFPNPLYQM 114

  Fly   127 LMGMAICDMLTVIFPAP-GLWYMYTFGNHYKPLH-PVSMCLAYSIFNEIMPAMCHTISVWLTLAL 189
            :..:..|..|:|:.|.| .:|| |..|...:.|: .::||..:....|.:|.|..|:....::.|
Worm   115 IWLLTFCGWLSVLSPLPFTVWY-YFVGEGTRSLNQSIAMCHLFRTSMETIPHMTDTMMTLFSVLL 178

  Fly   190 AVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLE 254
            |..|::...|....:. .|:.|..|....|..:.....:.|||:..........:..|
Worm   179 AAARFLTQYHRNTLKL-RTVERFSRAIWVIIFVCVTLAILRFFEHDTKVYQFCMDTEP------- 235

  Fly   255 TSMW-----VHDYIGVDLYYTSYYL-------FRVLFVHLLPCIILVTLNILLFAAMRQAQERRK 307
            |..|     |.|...:::...|::.       |.|.||  :|.::|..|::   ..:|:.:....
Worm   236 TPQWAGRCMVRDGALINIVNRSFWKVFLPLADFAVQFV--IPGVLLALLHV---GFIREPEIDMG 295

  Fly   308 LLFRENRKKECKKLRETNCTTLMLIVVVSV-FLLAEIPIAVVTAMHIV-------SSLIIEFLDY 364
            .|.:.||..     |.....|.:||..|:: ||:.::|.|.:|.:.:.       ::|::..|..
Worm   296 DLTKHNRFG-----RTPRDQTRILITTVTISFLVVQVPTAFITTLSLTINHFQNNNALMVLALVT 355

  Fly   365 G-----------LANICIMLTNFFLV 379
            |           .||...:||.::::
Worm   356 GHLQPLLSITTMAANTAALLTAYYVI 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	69/330 (21%)
		TM helix 1	92..116	CDD:410630	6/23 (26%)
		TM helix 2	124..146	CDD:410630	5/22 (23%)
		TM helix 3	169..191	CDD:410630	5/21 (24%)
		TM helix 4	214..230	CDD:410630	2/15 (13%)
		TM helix 5	270..293	CDD:410630	8/29 (28%)
		TM helix 6	328..353	CDD:410630	9/25 (36%)
		TM helix 7	368..393	CDD:410630	3/12 (25%)
K01A6.6	NP_001255582.1	7tm_GPCRs	118..351	CDD:333717	55/251 (22%)
		TM helix 3	154..180	CDD:320095	5/25 (20%)
		TM helix 4	205..218	CDD:320095	1/12 (8%)
		TM helix 5	261..283	CDD:320095	6/23 (26%)
		TM helix 6	312..334	CDD:320095	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004530
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47023
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100