DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and GPR142

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_861455.1	Gene:	GPR142 / 350383	HGNCID:	20088	Length:	462	Species:	Homo sapiens

Alignment Length:	341	Identity:	64/341 - (18%)
Similarity:	127/341 - (37%)	Gaps:	92/341 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMAT--PTNFVLMGMAICDMLTVIFPAPGLW 146
            |:.|...|.|..:|..|        |..:.|::.:..|  |:.:.|:.:...|::
Human   159 PVIYYSVLLGLGLPVSL--------LTAVALARLATRTRRPSYYYLLALTASDII---------- 205

  Fly   147 YMYTFGNHYKPLHPVSMCLAYSIF--------NEIMPAMCHT----------ISVWLTLALAVQR 193
                          :.:.:.::.|        .::..|:..|          .|||:.:.|.|.|
Human   206 --------------IQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDR 256

  Fly   194 YIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMW 258
            |..:||....|...:..|.||..|.:...|.|..:|.::   ::.:   |..:.:.....|...|
Human   257 YTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYW---WLDM---WRDTDSPRTLDEVLKW 315

  Fly   259 VHDYIGVDLYYTSYYLFRVLFVHLLPC-IILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLR 322
            .|                .|.|:.:|| :.|||.:.::....|:.        |...:....|
Human   316 AH----------------CLTVYFIPCGVFLVTNSAIIHRLRRRG--------RSGLQPRVGK-- 354

  Fly   323 ETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFG 387
                :|.:|:.:.::|.|...|...|...|:..:.:  ..|:.: ::.:.:.|...:.....|||
Human   355 ----STAILLGITTLFTLLWAPRVFVMLYHMYVAPV--HRDWRV-HLALDVANMVAMLHTAANFG 412

  Fly   388 IYCGMSRQFRETFKEI 403
            :||.:|:.||.|.:::
Human   413 LYCFVSKTFRATVRQV 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	61/330 (18%)
		TM helix 1	92..116	CDD:410630	5/23 (22%)
		TM helix 2	124..146	CDD:410630	2/21 (10%)
		TM helix 3	169..191	CDD:410630	7/39 (18%)
		TM helix 4	214..230	CDD:410630	4/15 (27%)
		TM helix 5	270..293	CDD:410630	7/23 (30%)
		TM helix 6	328..353	CDD:410630	6/24 (25%)
		TM helix 7	368..393	CDD:410630	6/24 (25%)
GPR142	NP_861455.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..123
GPR142	NP_861455.1	7tm_1	176..414	CDD:278431	52/300 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940