DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SPR and P2RY8

DIOPT Version :9

Sequence 1:NP_001368972.1 Gene:SPR / 31463 FlyBaseID:FBgn0029768 Length:512 Species:Drosophila melanogaster
Sequence 2:XP_006724506.2 Gene:P2RY8 / 286530 HGNCID:15524 Length:548 Species:Homo sapiens


Alignment Length:501 Identity:103/501 - (20%)
Similarity:181/501 - (36%) Gaps:175/501 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 QLEIPDYGNESLDYPNYQ-------QMVGGPCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLL 100
            |||.|......:..||..       ||:..|.           :....|:.|::         :.
Human   179 QLESPGEDPSRMQVPNSTGPDNATLQMLRNPA-----------IAVALPVVYSL---------VA 223

  Fly   101 IITIISNSLIVLVLSKK-SMATPTNFVLMGMAICD-MLTVIFPAPGLWYMYTFGNHYKPLHPVSM 163
            .::|..|...:.||.:: ...:|:...::.:::.| ||..:.|    :.:|...|.:..:..|.:
Human   224 AVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLP----FQIYYHCNRHHWVFGVLL 284

  Fly   164 C----LAY--SIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRR-----CT- 216
            |    :|:  ::::.|:...|          ::|:|::.|.:...::.|    |.||     |. 
Human   285 CNVVTVAFYANMYSSILTMTC----------ISVERFLGVLYPLSSKRW----RRRRYAVAACAG 335

  Fly   217 AYIALLAFLHQLPRFFDRTYMPL----------VIEWNGSPTEVCHLETSMWVHDYIGVDLYYTS 271
            .::.||..|..|.| .|.|| |:          |::|...|:      .:||            :
Human   336 TWLLLLTALSPLAR-TDLTY-PVHALGIITCFDVLKWTMLPS------VAMW------------A 380

  Fly   272 YYLFRV-LFVHLLPCIILV---TLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLI 332
            .:||.: :.:.|:|.:|.|   |..||            |||..|......::.|......::|:
Human   381 VFLFTIFILLFLIPFVITVACYTATIL------------KLLRTEEAHGREQRRRAVGLAAVVLL 433

  Fly   333 VVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLA-------NICIMLTNFFLVFSYPINFGIYC 390
            ..|:.|    .|...|...||||.|.     ||.:       .:|:...|..|   .|.   :|.
Human   434 AFVTCF----APNNFVLLAHIVSRLF-----YGKSYYHVYKLTLCLSCLNNCL---DPF---VYY 483

  Fly   391 GMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVLXXLVMLVPRRGSSDHRRSST 455
            ..||:|:...:| :||                    |..            || |.:.|.||.|.
Human   484 FASREFQLRLRE-YLG--------------------CRR------------VP-RDTLDTRRESL 514

  Fly   456 STTTTTTTKTIGGSMIIGGEASAQHQHLVTHHLQTHSQPSQQRRVS 501
            .:..||:.::..|:...|.|.:              ::|..||:.|
Human   515 FSARTTSVRSEAGAHPEGMEGA--------------TRPGLQRQES 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPRNP_001368972.1 7tmA_FMRFamide_R-like 90..400 CDD:410630 72/344 (21%)
TM helix 1 92..116 CDD:410630 4/23 (17%)
TM helix 2 124..146 CDD:410630 4/22 (18%)
TM helix 3 169..191 CDD:410630 2/21 (10%)
TM helix 4 214..230 CDD:410630 6/21 (29%)
TM helix 5 270..293 CDD:410630 7/26 (27%)
TM helix 6 328..353 CDD:410630 5/24 (21%)
TM helix 7 368..393 CDD:410630 5/24 (21%)
P2RY8XP_006724506.2 7tm_4 222..>321 CDD:304433 19/112 (17%)
7tm_1 229..482 CDD:278431 67/317 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

Return to query results.
Submit another query.