DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and P2RY10

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001311154.1	Gene:	P2RY10 / 27334	HGNCID:	19906	Length:	364	Species:	Homo sapiens

Alignment Length:	392	Identity:	76/392 - (19%)
Similarity:	151/392 - (38%)	Gaps:	110/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RMEDNNISYWNLTCD-SPLEYAMPLYGYCMPFLLIITIISNSLIVLVL----SKKSMATPTNFVL 127
            :|..|:.|...:.|: :.:::...||......:.|..:::||..:.||    |||:.|.   ..:
Human    37 KMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAI---IFM 98

  Fly   128 MGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLA--YSIFNEIMPAMCHTISVWLTLALA 190
            :.:::.|:..|:.....::|   :.:|:.|... ::||.  |..:..:..::|     :|| .::
Human    99 INLSVADLAHVLSLPLRIYY---YISHHWPFQR-ALCLLCFYLKYLNMYASIC-----FLT-CIS 153

  Fly   191 VQRYIYVCHAPMARTWCTMPRVRR----CTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVC 251
            :||..::.....||.|     .||    .:|.|.::.....||       .|::...:.:..:.|
Human   154 LQRCFFLLKPFRARDW-----KRRYDVGISAAIWIVVGTACLP-------FPILRSTDLNNNKSC 206

  Fly   252 HLETSMWVHDYIGVDLYY---TSYYLFRVLFV-----HLLPCIILVTLNILLFAAMRQ------- 301
            .            .||.|   .:..|..::.|     .::|.||:.........::||
Human   207 F------------ADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQG 259

  Fly   302 AQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAV------VTAMHIVSSL-II 359
            ..||:|.|                   .|:.:..:||.:...|..:      :....|:||. ::
Human   260 ISERQKAL-------------------RMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVV 305

  Fly   360 EFLDY------GLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETF----KEIFLGRLMAKKDS 414
            ....|      .||::|.:|.        ||   :|..|:.:||:..    ..:...|||:|:..
Human   306 RIALYFHPFCLCLASLCCLLD--------PI---LYYFMASEFRDQLSRHGSSVTRSRLMSKESG 359

  Fly   415 ST 416
            |:
Human   360 SS 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	67/347 (19%)
		TM helix 1	92..116	CDD:410630	6/27 (22%)
		TM helix 2	124..146	CDD:410630	2/21 (10%)
		TM helix 3	169..191	CDD:410630	3/21 (14%)
		TM helix 4	214..230	CDD:410630	4/19 (21%)
		TM helix 5	270..293	CDD:410630	5/27 (19%)
		TM helix 6	328..353	CDD:410630	4/30 (13%)
		TM helix 7	368..393	CDD:410630	5/24 (21%)
P2RY10	NP_001311154.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000