Protein Alignment SPR and sprr-3

DIOPT Version :9

• Sequence 1: NP_001368972.1
• Gene: SPR / 31463
• FlyBaseID: FBgn0029768
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_500218.2
• Gene: sprr-3 / 190541
• WormBaseID: WBGene00022086
• Length: 465
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 123/510 - (24%)
• Similarity: 216/510 - (42%)
• Gaps: 101/510 - (19%)

  Fly    22 EMELADPRQMVRGFHLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDNNISYWNLTCDSPLE 86
            ::|:.|       :...||..|....|||    .|..|.|.. .|.::    |.:.::..|..|:
 Worm     3 DLEICD-------YDETTNNRQNCTEDYG----VYDGYTQTC-VPLQL----IQFEDVENDVKLQ 51

  Fly    87 YAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTVIFPAPGLWYMYTF 151
            .   :||..:|.|.::.::|||:::||||::.....:...|:.||||.:|..|.|.|...|.|..
 Worm    52 I---IYGIILPVLAVLVVVSNSVVILVLSQQKSKRASVEPLLWMAICSLLMAISPLPFTIYYYNL 113

  Fly   152 GNHYKPLHPVSMCLAYSIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCT 216
            .:|......:.:|....:..||||...:.:.:..|:.|.|||:|.|.:...:..|||...|||.:
 Worm   114 SHHLDFNQTLFLCYLQKVCMEIMPFFFNNLVLLFTILLGVQRFIVVQYPLQSIRWCTPKMVRRYS 178

  Fly   217 AYIALLA-FLHQLPRFFD-RTYMPLVIEWNGSPTEVCHLETSMWV----------HDYIGVDLYY 269
            ..|.:|| ||......:| |......|::.         :.|.||          ....|.|.:.
 Worm   179 KLILILATFLTGFHSLYDIRLLYHFCIKYR---------DESFWVARCFIGYSSLTSAFGADAFS 234

  Fly   270 TSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFR-ENRKKECKKLRETNCTTLMLIV 333
            ..:..||:. ::||...:|..:.|||...:|.....::.:.| :|||....       ||:||.|
 Worm   235 ALFDYFRIT-INLLASGLLFVVTILLIQTIRTHDHPKQGVHRHKNRKTSAN-------TTIMLTV 291

  Fly   334 VVSVFLLAEIPIAVVTAMHIVSSLIIEFLDY-GLANICI-MLTNFFL-VFS-------YPINFGI 388
            ::.:::||.:|..::       .|:::.:|| .:..|.. ::.|.:| ||:       :||:|.|
 Worm   292 IIIIYMLARVPTTLL-------FLLVKLMDYISVPTIAFEVMNNIYLRVFANITTISLHPISFAI 349

  Fly   389 YCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVLXXLVMLVPRRGSSDHRRS 453
            |..|||:||.:.:.:...|.:|..:....::                           ||....:
 Worm   350 YMFMSRKFRVSMRRLLGWRFLASDEEFNAFT---------------------------SSTRIHT 387

  Fly   454 STSTTTTTTTKTIG----GSMIIGGEASAQHQHLVTHHLQTHSQPSQQRRVSTMD 504
            :....|....::||    |:..:|.:....    |...:....:|.::||.:|.|
 Worm   388 AHPKMTLMEKESIGSSGKGTPSVGQKRGMS----VDFKISFDVEPQRRRRATTAD 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	93/332 (28%)
		TM helix 1	92..116	CDD:410630	10/23 (43%)
		TM helix 2	124..146	CDD:410630	9/21 (43%)
		TM helix 3	169..191	CDD:410630	6/21 (29%)
		TM helix 4	214..230	CDD:410630	6/16 (38%)
		TM helix 5	270..293	CDD:410630	5/22 (23%)
		TM helix 6	328..353	CDD:410630	7/24 (29%)
		TM helix 7	368..393	CDD:410630	10/33 (30%)
sprr-3	NP_500218.2	7tm_GPCRs	89..358	CDD:391938	80/292 (27%)
		TM helix 2	89..110	CDD:341315	9/20 (45%)
		TM helix 3	128..160	CDD:341315	10/31 (32%)
		TM helix 4	172..201	CDD:341315	10/28 (36%)
		TM helix 5	234..258	CDD:341315	5/24 (21%)
		TM helix 6	279..316	CDD:341315	12/50 (24%)
		TM helix 7	329..354	CDD:341315	8/24 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421120at33208
OrthoFinder	1	1.000	-	-		FOG0004530
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47023
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.040