DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPR and dmsr-2

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_490992.2	Gene:	dmsr-2 / 189527	WormBaseID:	WBGene00021275	Length:	407	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	99/378 - (26%)
Similarity:	166/378 - (43%)	Gaps:	73/378 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 YGYCMPFLLIITIISNSLIVLVLSKKSM-ATPTNFVLMGMAICDMLTVIFPAPGLWYMYTFGNHY 155
            :.|...||.:|.:.:|..||:||.:.:| .:|.|..|:.:|:||        ..|...|....|.
Worm    33 HNYIYVFLCVIGVFANISIVVVLLRPAMRKSPFNLFLVVIAVCD--------ASLMATYLTYKHV 89

  Fly   156 KPLHPVSMCLAYSIFNE---IMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRC-- 215
            :..||......::|:.:   |.....|:.|:|||:.:|:.|::.:.....:.|     |:.:|
Worm    90 ELCHPWYFSFPWAIYTKFYAIFSVFVHSCSLWLTVNMAILRFLVLYRGSRSET-----RIPQCNG 149

  Fly   216 --TAYIAL-LAF----LHQLPRFFDRTYMPLVIEWN-GSPTEVCHLE----TSMWVHDYIGVDLY 268
              .|::|: |||    :..||.|.  .|.  :||.. |:..::| ||    |....:|.|  ..|
Worm   150 FGAAFVAIVLAFAIACIGCLPIFI--RYR--IIEGEVGAVPDLC-LEGKYSTDWQPNDMI--QFY 207

  Fly   269 YTSY------------YLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKL 321
            ..|.            |....|.:.|:||::|.....||...:.:|:|||..|        |..:
Worm   208 GLSQPLWWNCDWERINYWMAALILKLIPCLLLTIFMTLLVRMLIEARERRSRL--------CGGM 264

  Fly   322 RETNC----TTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSY 382
            ...|.    ||.||..:|::||:.|:|..|:| ....::..:.||...:.|:..:|:    :.:.
Worm   265 GNGNSQAERTTAMLTGIVAIFLITELPQGVLT-FAAGANPRLTFLTLQMNNVFDLLS----LINS 324

  Fly   383 PINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVL 435
            .:||.:...||..||..|.:.| |  :....||..:|   ||.....:|.::|
Worm   325 AVNFVLCALMSHVFRREFLQTF-G--VCCPQSSENHS---GAPINKTSNRSIL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	89/341 (26%)
		TM helix 1	92..116	CDD:410630	9/23 (39%)
		TM helix 2	124..146	CDD:410630	5/21 (24%)
		TM helix 3	169..191	CDD:410630	7/24 (29%)
		TM helix 4	214..230	CDD:410630	7/24 (29%)
		TM helix 5	270..293	CDD:410630	7/34 (21%)
		TM helix 6	328..353	CDD:410630	10/24 (42%)
		TM helix 7	368..393	CDD:410630	4/24 (17%)
dmsr-2	NP_490992.2	7tmA_FMRFamide_R-like	32..342	CDD:320109	89/341 (26%)
		TM helix 1	33..57	CDD:320109	9/23 (39%)
		TM helix 2	66..92	CDD:320109	8/33 (24%)
		TM helix 3	106..128	CDD:320109	6/21 (29%)
		TM helix 4	155..171	CDD:320109	5/15 (33%)
		TM helix 5	221..244	CDD:320109	6/22 (27%)
		TM helix 6	273..297	CDD:320109	11/24 (46%)
		TM helix 7	311..335	CDD:320109	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004530
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000