DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and frpr-8

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_509470.3	Gene:	frpr-8 / 186144	WormBaseID:	WBGene00018728	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	404	Identity:	94/404 - (23%)
Similarity:	168/404 - (41%)	Gaps:	97/404 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TCDSPLEYA------MPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTV 138
            ||..|..:|      ..:|...:|.:.::...:..:.::|.::|.|.:..|..|.|:::.|::.:
Worm    29 TCSYPTNFAEVDYISTYIYLLAIPTICVLGAGAAVMCIVVFTRKQMRSSLNVYLAGLSVFDLILL 93

  Fly   139 IFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAMCHTI-----------------SVWLT 186
            .|.|      ..|.       |:..|:.....:   .|:||..                 |||..
Worm    94 SFSA------LIFS-------PLQGCVLQGHGD---TAVCHFFWRSTPWTLPISNIAQCGSVWTC 142

  Fly   187 LALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAF--LHQLPRFFDRTYMPLVIEWNGSPTE 249
            :|:.|.|::.|.:...::.||| || |..|..||:..|  |.:.|.||:.|            .:
Worm   143 VAVTVDRFLAVNYPLHSKIWCT-PR-RATTILIAITVFSILFKAPMFFELT------------ND 193

  Fly   250 VC-HLETSMWVHDYIGVDLYYTSYYL-FRVLFVHLL-PCIILVTLNILLFAAMRQAQE-RRKLLF 310
            .| .|.||     ::..:.||..||: |..|...|| |..:::.||:.:..|:.:|.: ||.:..
Worm   194 DCGRLRTS-----FLRDNKYYKEYYVTFGYLIALLLIPWTVMIILNVFVVKAVHKAYKIRRSMQG 253

  Fly   311 RENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTN 375
            .:|.::|    ::..| |||.|.:|..||:..:..||......|..:.:.|.. .:.|:.|.|.:
Worm   254 GKNNQEE----KDRRC-TLMAIAMVLTFLIFNVVAAVNNLAETVFEVSLGFWS-PIGNLLICLNS 312

  Fly   376 FFLVFSYPINFG---------IYCGMSRQFRETFKEIFLGRLMAK--------KDSSTKYSIVN- 422
            ...:..|.: ||         :.||...::.|..|   :||...:        :|.:|:.:.::
Worm   313 ASNIVIYSL-FGARFRQMCVLMLCGRQSRWMEWLK---VGRYPPQSMVSDWDGRDGTTRKTSLDA 373

  Fly   423 -----GARTCTNTN 431
                 .||..|.:|
Worm   374 STALLSARRMTISN 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	81/341 (24%)
		TM helix 1	92..116	CDD:410630	3/23 (13%)
		TM helix 2	124..146	CDD:410630	6/21 (29%)
		TM helix 3	169..191	CDD:410630	7/38 (18%)
		TM helix 4	214..230	CDD:410630	5/17 (29%)
		TM helix 5	270..293	CDD:410630	8/24 (33%)
		TM helix 6	328..353	CDD:410630	9/24 (38%)
		TM helix 7	368..393	CDD:410630	8/33 (24%)
frpr-8	NP_509470.3	7tmA_FMRFamide_R-like	45..330	CDD:320109	78/326 (24%)
		TM helix 1	47..71	CDD:320109	3/23 (13%)
		TM helix 2	79..101	CDD:320109	6/27 (22%)
		TM helix 3	125..147	CDD:320109	4/21 (19%)
		TM helix 4	170..186	CDD:320109	5/15 (33%)
		TM helix 5	212..235	CDD:320109	8/22 (36%)
		TM helix 6	263..288	CDD:320109	10/25 (40%)
		TM helix 7	301..323	CDD:320109	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010