DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and egl-6

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001257033.1	Gene:	egl-6 / 183513	WormBaseID:	WBGene00001175	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	96/416 - (23%)
Similarity:	167/416 - (40%)	Gaps:	112/416 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITII---SNSLIVLVLSKKSMATPTNFVLMG 129
            |....|:|...:|..|.|:|...::   :|..:.|.|.   ||...::||::|.|.||.|.:|.|
Worm    12 RENATNVSSRAITDKSFLQYYDEIH---IPLSISICIFGAASNVFNIIVLTRKRMRTPINILLTG 73

  Fly   130 MAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCL---------AYSIFNEIMPAMCHTISVWL 185
            ::|...|...     .:::|....:|:     ..|:         .|..||..:..:.|||:...
Worm    74 LSIAQWLLAT-----NYFLYLLLEYYR-----YQCVQLLWSEAFTRYRFFNVNLNTVFHTIAFTT 128

  Fly   186 TLALAVQRY------------IYVCHAPMART---WCTMPRVRRCTAYIALLAFLHQLPRFF--- 232
            |:.:||.||            ||.|...:|..   |..:|.:              .||.||
Worm   129 TIVVAVFRYCALKFPIQANRFIYKCQPAIAANVIIWIIIPII--------------SLPLFFISE 179

  Fly   233 ------DRTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTL 291
                  |.....|..|..|...::.:.|:.:         |....::.|.::| .|||.:||..|
Worm   180 VKIVARDHVAYDLQCEMEGPLYDLSYQESPL---------LVSAVFWAFGIVF-KLLPSLILSIL 234

  Fly   292 NILLFAAMRQAQERRKLLFR--------ENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVV 348
            .|.|..:::..:.|||...|        .:.:|..:||.....||.||::::.:.::.|:|:.::
Worm   235 LIALIRSLKSVERRRKNWKRTQGANICTNSERKAKRKLTTRPRTTRMLVIILLLCVMVELPMGIL 299

  Fly   349 TAMHIVSSLIIEFLDYG----------LANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEI 403
            .....:         ||          :.|:..|||   |::| .::|.:||.||.::..||:.:
Worm   300 NLCVAI---------YGEEFGNRYYDPVGNLMEMLT---LLYS-SVSFVLYCTMSNEYLSTFRAL 351

  Fly   404 FLGRLMAKKDSSTKYSIVNGARTCTN 429
            |.        ..|:.:.:.|.|...|
Worm   352 FF--------PWTRKNSLRGTRRSWN 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	82/363 (23%)
		TM helix 1	92..116	CDD:410630	7/26 (27%)
		TM helix 2	124..146	CDD:410630	5/21 (24%)
		TM helix 3	169..191	CDD:410630	6/21 (29%)
		TM helix 4	214..230	CDD:410630	1/15 (7%)
		TM helix 5	270..293	CDD:410630	8/22 (36%)
		TM helix 6	328..353	CDD:410630	5/24 (21%)
		TM helix 7	368..393	CDD:410630	9/24 (38%)
egl-6	NP_001257033.1	7tmA_FMRFamide_R-like	35..348	CDD:320109	82/362 (23%)
		TM helix 1	35..61	CDD:320109	7/28 (25%)
		TM helix 2	67..92	CDD:320109	6/29 (21%)
		TM helix 3	111..141	CDD:320109	10/29 (34%)
		TM helix 4	154..174	CDD:320109	4/33 (12%)
		TM helix 5	212..237	CDD:320109	8/25 (32%)
		TM helix 6	273..303	CDD:320109	6/29 (21%)
		TM helix 7	316..341	CDD:320109	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004530
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000