DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPR and dmsr-8

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_505697.3	Gene:	dmsr-8 / 183225	WormBaseID:	WBGene00007951	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	105/422 - (24%)
Similarity:	182/422 - (43%)	Gaps:	84/422 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 NLTCDSPLEYAM----PLYGYCMPFLLIITIIS----NSLIVLVLSKKSMATPTNFVLMGMAICD 134
            |.|....||.|:    ..|.:..|::.:|..::    |.:.|:||::.||.:..|.:|..:|:||
Worm     9 NFTGAEWLETAVTNINTAYAHIHPYVSVILCLAGTAMNIVTVIVLTRPSMRSAVNSLLCAIALCD 73

  Fly   135 MLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSI-FNEIMPAMCHTISVWLTLALAVQRYIYVC 198
            :|.:......:.:...|..:.......::..||.: ::.....:.|..|:|||:.||..|...:.
Worm    74 ILVMTSVLVFVTHFLLFAGYRCDPTDYNIYWAYFLYYHSQATVIFHATSIWLTVLLAQIRVFSIR 138

  Fly   199 HA-PMARTWCTMPRVRRCTAYIALLAF----LHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMW 258
            .| .:|....|    .:.|..||:..|    |..:|...  |:            |:.....|:|
Worm   139 RATSVAGESVT----NQMTCIIAVTTFIVVCLLNVPNML--TF------------EIIETPASLW 185

  Fly   259 VH-------------------DYIGV--DLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQA 302
            :.                   |:.|:  ..::|:..||:|     :||::|....:.|.:.:|..
Worm   186 LQCKANETAEDDMLVYLVAPSDHCGLLNIAFWTNGVLFKV-----VPCLLLTFSIVALVSIIRDV 245

  Fly   303 QERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIE--FLDYG 365
            .:|||.|.:...||...:    :.||.||:.|:|:||.||:|..|   :|:.:::..:  |.|
Worm   246 GKRRKQLAQVMNKKRMPR----DHTTPMLVAVLSIFLFAELPQGV---LHVFNAIFTKETFYD-- 301

  Fly   366 LANICIMLTNFFLVFSY---PINFGIYCGMSRQFRETFKEIFLGRL---MAKKDSSTKYSIVNGA 424
              .|.|.|.:...|.|.   .:||.|||.|||:||..|.:|||..|   :.:|.:...:..|..:
Worm   302 --KIYIHLGDVMDVLSLLNSAVNFIIYCAMSRKFRAVFIQIFLTCLPQKIIRKYAMEAFLDVEVS 364

  Fly   425 RTCTNTNETVLXXLVMLVPRRGSSDHRRSSTS 456
            |.....:.|....|.:       :.||.|::|
Worm   365 RMRPTADMTKSEQLAL-------TSHRVSASS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	86/345 (25%)
		TM helix 1	92..116	CDD:410630	7/27 (26%)
		TM helix 2	124..146	CDD:410630	6/21 (29%)
		TM helix 3	169..191	CDD:410630	6/22 (27%)
		TM helix 4	214..230	CDD:410630	5/19 (26%)
		TM helix 5	270..293	CDD:410630	7/22 (32%)
		TM helix 6	328..353	CDD:410630	11/24 (46%)
		TM helix 7	368..393	CDD:410630	10/27 (37%)
dmsr-8	NP_505697.3	7tmA_FMRFamide_R-like	30..337	CDD:320109	85/340 (25%)
		TM helix 1	31..55	CDD:320109	6/23 (26%)
		TM helix 2	63..85	CDD:320109	6/21 (29%)
		TM helix 3	109..131	CDD:320109	6/21 (29%)
		TM helix 4	155..171	CDD:320109	4/15 (27%)
		TM helix 5	213..236	CDD:320109	7/27 (26%)
		TM helix 6	264..289	CDD:320109	12/27 (44%)
		TM helix 7	305..330	CDD:320109	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004530
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000